Basic Description

Synonyms	L-Ornithine hydrochloride \| 3184-13-2 \| L(+)-Ornithine hydrochloride \| L-Ornithine monohydrochloride \| L-ORNITHINE HCl \| H-Orn-OH.HCl \| (S)-2,5-Diaminopentanoic acid hydrochloride \| Ornithine hydrochloride \| L-Ornithine, monohydrochloride \| Ornithine monohydrochloride \| MFCD
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle.Nonproteinogenic amino acid. Intermediate metabolite in the urea cycle. Necessary for the biosynthesis of L-arginine, L-proline and polya
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	L-Ornithine Hydrochloride is a nonprotein amino acid. It is used in the body in the biosynthesis of L-arginine, L-proline and polyamines.Product of arginine degradation by arginase 。 Soluble in water (543 mg/ml at 20 °C), and alcohol. Optical Activity: α20/D +23.0o±0.5o, c = 5 in 5 M HCl; α20/D +23.5o±1.5o, c = 4 in 6 mol/L HCl; α24/D +23.6o, c = 4 in 6 M HCl; α25/D +22.5o±0.7o, c = 2 in 5 M HCl IC50: mGluR-2: EC5050 = 35 μM (human); mGluR-2: EC5050 = 35 μM (rat); mGluR-6: EC5050 = 140 μM (rat); mGluR-6: EC5050 = 140 μM (human); mGluR-5: EC5050 >1 mM (rat) Ki Data: mGluR-2: Ki= 35 μM (human); mGluR-6: Ki= 140 μM (human); mGluR-5: Ki>1 mM (human); mGluR-1a: Ki>1 mM (human); mGluR-4: Ki>3 mM (human) A nonprotein amino acid used in the biosynthesis of L-arginine, L-proline and polyamines.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids
        Level8 L-alpha-amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct Parent	L-alpha-amino acids
Alternative Parents	Fatty acids and conjugates Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic acyclic compounds
Substituents	L-alpha-amino acid - Fatty acid - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Hydrochloride - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Organopnictogen compound - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-2,5-diaminopentanoic acid;hydrochloride
INCHI	InChI=1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
InChIKey	GGTYBZJRPHEQDG-WCCKRBBISA-N
Smiles	Cl.NCCC[C@H](N)C(O)=O
Isomeric SMILES	C(C[C@@H](C(=O)O)N)CN.Cl
RTECS	RM2985000
Alternate CAS	70-26-8
Molecular Weight	168.62
Beilstein	4420
Reaxy-Rn	4328590
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4328590&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Sensitivity	Hygroscopic
Refractive Index	1.52
Specific Rotation[α]	+22.0 to +25.0 deg(C=4, 6mol/L HCl)
Boil Point(°C)	308.7 °C
Melt Point(°C)	245℃
Molecular Weight	168.620 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	168.067 Da
Monoisotopic Mass	168.067 Da
Topological Polar Surface Area	89.300 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	95.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Zhou Kai, Zhang Xiao, Li Bingyong, Shen Chaoqun, Sun Yuan-Ming, Yang Jianyuan, Xu Zhen-Lin. (2021) Citrulline Accumulation Mechanism of Pediococcus acidilactici and Weissella confusa in Soy Sauce and the Effects of Phenolic Compound on Citrulline Accumulation. Frontiers in Microbiology, 12
2. Chengyi Xie, Liancheng Gu, Qidi Wu, Lei Li, Chenlu Wang, Jiancheng Yu, Keqi Tang. (2021) Effective Chiral Discrimination of Amino Acids through Oligosaccharide Incorporation by Trapped Ion Mobility Spectrometry. ANALYTICAL CHEMISTRY, 93 (2): (859–867).
3. Lili Zhang, Wen Duan, Yan Huang, Yuyu Zhang, Baoguo Sun, Dandan Pu, Yizhuang Tang, Chao Liu. (2020) Sensory taste properties of chicken (Hy-Line brown) soup as prepared with five different parts of the chicken. INTERNATIONAL JOURNAL OF FOOD PROPERTIES,
4. Bi Guoshu, Liang Jiaqi, Bian Yunyi, Shan Guangyao, Huang Yiwei, Lu Tao, Zhang Huan, Jin Xing, Chen Zhencong, Zhao Mengnan, Fan Hong, Wang Qun, Gan Boyi, Zhan Cheng. (2024) Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer. Nature Communications, 15 (1): (1-20).

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L-Ornithine monohydrochloride - 10mM in Water, high purity , CAS No.3184-13-2