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L-366,948, Antagonist of OT receptor, CAS No.127819-97-0, Antagonist of OT receptor

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rp174428
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rp174428-500μg
500μg
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$1,334.90
rp174428-1mg
1mg
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OT receptor Antagonist (33)

Basic Description

Product Name L-366,948, Antagonist of OT receptor, CAS No.127819-97-0
Synonyms GTPL2245 | 2-Amino-N-[1-(1-{3-[2,2-di(piperidine-1-carbonyl)-2H-imidazol-4-yl]alanyl}-2-formylpyrrolidin-2-yl)-3-methyl-1-oxopentan-2-yl]-3-(naphthalen-2-yl)propanimidic acid | (2S)-2-amino-N-[(2S,3S)-1-[(2S)-1-[(2R)-2-amino-3-[2,2-bis(piperidine-1-carbon
Grade Moligand™
Specifications & Purity Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of OT receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent Alpha amino acid amides
Alternative Parents Naphthalenes  N-acylpiperidines  N-acylpyrrolidines  Aralkylamines  Fatty amides  Tertiary carboxylic acid amides  Secondary carboxylic acid amides  Ketones  Ketimines  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Aldehydes  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Alpha-amino acid amide - Naphthalene - N-acyl-piperidine - N-acylpyrrolidine - Aralkylamine - Fatty acyl - Benzenoid - Piperidine - Fatty amide - Tertiary carboxylic acid amide - Pyrrolidine - Secondary carboxylic acid amide - Ketone - Ketimine - Carboxamide group - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Imine - Carbonyl group - Amine - Aldehyde - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
External Descriptors Not available

Associated Targets(Human)

OXTR Tclin Oxytocin receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

CAS 127819-97-0

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names GTPL2245 | 2-Amino-N-[1-(1-{3-[2,2-di(piperidine-1-carbonyl)-2H-imidazol-4-yl]alanyl}-2-formylpyrrolidin-2-yl)-3-methyl-1-oxopentan-2-yl]-3-(naphthalen-2-yl)propanimidic acid | (2S)-2-amino-N-[(2S,3S)-1-[(2S)-1-[(2R)-2-amino-3-[2,2-bis(piperidine-1-carbon
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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