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L-152,804 - ≥99%(HPLC), high purity , CAS No.6508-43-6

COA

Grade & Purity:

≥99%(HPLC)

Cas Number: 6508-43-6
Molecular Weight: 366.46
PubChem CID: 3765615
PubChem SID: 504762713

In stock

Item Number

L288948

Grouped product items
SKU	Size	Availability	Price
L288948-5mg	5mg	2	$88.90
L288948-10mg	10mg	2	$147.90
L288948-25mg	25mg	2	$333.90
L288948-50mg	50mg	2	$444.90
L288948-100mg	100mg	2	$741.90

Potent, selective non-peptide NPY Y5receptor antagonist

View related series

Class A GPCR (4138) GPCR/G Protein (3172) Neuronal Signaling (3320) Neuropeptide Y Receptor (49)

Basic Description

Synonyms	SCHEMBL1119012 \| EC-000.2413 \| SR-01000030470 \| SR-01000030470-1 \| 1,3-Cyclohexanedione, 5,5-dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)- \| 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione \|
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Potent, selective non-peptide neuropeptide Y Y5receptor antagonist (Ki= 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centra
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzopyrans
    - Subclass 1-benzopyrans
      - Level5 Dibenzopyrans
        Level6 Xanthenes

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzopyrans
Subclass	1-benzopyrans
Intermediate Tree Nodes	Dibenzopyrans
Direct Parent	Xanthenes
Alternative Parents	Cyclohexenones Beta-diketones Benzenoids Vinylogous esters Oxacyclic compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Xanthene - Cyclohexenone - 1,3-diketone - Benzenoid - 1,3-dicarbonyl compound - Vinylogous ester - Cyclic ketone - Ketone - Oxacycle - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

Discover Target: GNAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EYA2 Tbio Eyes absent homolog 2 (5884 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504762713
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504762713
IUPAC Name	2-(3,3-dimethyl-1-oxo-4,9-dihydro-2H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione
INCHI	InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3
InChIKey	XQDXIHYKAGHZRX-UHFFFAOYSA-N
Smiles	CC1(CC(=O)C(C(=O)C1)C2C3=CC=CC=C3OC4=C2C(=O)CC(C4)(C)C)C
Isomeric SMILES	CC1(CC(=O)C(C(=O)C1)C2C3=CC=CC=C3OC4=C2C(=O)CC(C4)(C)C)C
WGK Germany	3
Molecular Weight	366.46
Reaxy-Rn	1298657
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1298657&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2304695	Certificate of Analysis	Oct 31, 2022	L288948
C2304677	Certificate of Analysis	Oct 31, 2022	L288948
C2304648	Certificate of Analysis	Oct 31, 2022	L288948
C2515082	Certificate of Analysis	Oct 31, 2022	L288948
C2304679	Certificate of Analysis	Oct 31, 2022	L288948
C2304692	Certificate of Analysis	Oct 31, 2022	L288948

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 36.65, Max Conc. mM: 100
Molecular Weight	366.400 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	366.183 Da
Monoisotopic Mass	366.183 Da
Topological Polar Surface Area	60.400 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	707.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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