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KY02111 - ≥98%, high purity , CAS No.1118807-13-8

    Grade & Purity:
  • ≥98%
In stock
Item Number
K129803
Grouped product items
SKU Size
Availability
Price Qty
K129803-10mg
10mg
3
$70.90
K129803-50mg
50mg
2
$284.90

Promotes differentiation of hPSCs to cardiomyoctes. Wnt pathway inhibitor.

View related series
Stem Cell/Wnt (1019) Wnt (104)

Basic Description

Synonyms EN300-1266069 | UNII-6AXH36YF6M | AS-16445 | DTXSID80429194 | MFCD08483062 | KY02111 | KY-02111 | UNII-A4125MQ8RX | 2-(3-(3,4-Dimethoxyphenyl)propanamido)-6-chlorobenzothiazole | S7096 | AM81229 | C18H17ClN2O3S | N-(6-Chloro-benzothiazol-2-yl)-3-(3,4-dime
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms KY02111 promotes differentiation of human pluripotent stem cells (hPSCs) to cardiomyocytes by inhibiting WNT signaling in hPSCs in a manner that is distinct from that of previously studied WNT inhibitors. The substantial (98%) differentiation of hPSCs to
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
A Wnt inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Methoxybenzenes
Intermediate Tree Nodes Not available
Direct Parent Dimethoxybenzenes
Alternative Parents Benzothiazoles  Phenoxy compounds  N-arylamides  Anisoles  Alkyl aryl ethers  Fatty amides  Aryl chlorides  Thiazoles  Heteroaromatic compounds  Secondary carboxylic acid amides  Azacyclic compounds  Organochlorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents O-dimethoxybenzene - Dimethoxybenzene - 1,3-benzothiazole - Phenoxy compound - Anisole - Phenol ether - N-arylamide - Alkyl aryl ether - Aryl chloride - Aryl halide - Fatty amide - Fatty acyl - Heteroaromatic compound - Azole - Thiazole - Carboxamide group - Secondary carboxylic acid amide - Ether - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Organic nitrogen compound - Organohalogen compound - Organochloride - Carbonyl group - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as dimethoxybenzenes. These are organic aromatic compounds containing a monocyclic benzene moiety carrying exactly two methoxy groups.
External Descriptors Not available

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name N-(6-chloro-1,3-benzothiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide
INCHI InChI=1S/C18H17ClN2O3S/c1-23-14-7-3-11(9-15(14)24-2)4-8-17(22)21-18-20-13-6-5-12(19)10-16(13)25-18/h3,5-7,9-10H,4,8H2,1-2H3,(H,20,21,22)
InChIKey LXFKEVQQSKQXPR-UHFFFAOYSA-N
Smiles COC1=C(C=C(C=C1)CCC(=O)NC2=NC3=C(S2)C=C(C=C3)Cl)OC
Isomeric SMILES COC1=C(C=C(C=C1)CCC(=O)NC2=NC3=C(S2)C=C(C=C3)Cl)OC
WGK Germany 3
Molecular Weight 376.86
Reaxy-Rn 23763295
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23763295&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
J1515146 Certificate of Analysis May 10, 2023 K129803
K1821169 Certificate of Analysis Jul 18, 2022 K129803

Chemical and Physical Properties

Solubility DMSO 75 mg/mL Water Ethanol
Molecular Weight 376.900 g/mol
XLogP3 4.300
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 6
Exact Mass 376.065 Da
Monoisotopic Mass 376.065 Da
Topological Polar Surface Area 88.700 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 456.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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