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kira6 - 98%, high purity , CAS No.1589527-65-0

COA

Grade & Purity:

≥98%

Cas Number: 1589527-65-0
Molecular Weight: 518.53
PubChem CID: 73425700
PubChem SID: 504772329

In stock

Item Number

K414099

Grouped product items
SKU	Size	Availability	Price
K414099-2mg	2mg	3	$56.90
K414099-5mg	5mg	3	$117.90
K414099-10mg	10mg	3	$177.90
K414099-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
K414099-50mg	50mg	2	$622.90

IRE1 Inhibitors

View related series

Cell Cycle/DNA Damage (2602) IRE1 (30) Unfolded Protein Response (214)

Basic Description

Synonyms	EN300-195606 \| 1589527-65-0 \| AC-36160 \| SCHEMBL16964584 \| Z2689324163 \| s8658 \| CCG-269842 \| KIRA 6 \| NOHQEAFAESMMDX-UHFFFAOYSA-N \| EX-A2581 \| AB90807 \| Urea, N-[4-[8-amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoro
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information kira6 kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization. Targets IRE1α (Cell-free) 0.6 μM In vitro In INS-1 cells, KIRA6 inhibits IRE1α auto-phosphorylation by Tg and XBP1 mRNA splicing by Tm in a dose-dependent manner. In vivo Intravitreally, KIRA6 preserves photoreceptor functional viability in rat models of ER stress-induced retinal degeneration. Systemically, KIRA6 preserves pancreatic β-cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice. KIRA6 inhibits IRE1α in vivo to preserve cell viability and function in diverse cells and rodent tissues experiencing ER stress. The pharmacokinetic profile of KIRA6 in BALB/c mice intraperitoneally (i.p.) dosed at 10 mg/kg shows good drug plasma AUC levels (AUC 0-24h = 14.3 μM*h) with moderate clearance (22.4 mL/min/kg). Drug half-life is 3.90 hours, Cmax is 3.3 μM, and plasma levels at 4 and 8hr are 1.2 μM and 0.33 μM, respectively.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Naphthalenes
Alternative Parents	Trifluoromethylbenzenes N-phenylureas Imidazo[1,5-a]pyrazines Aminopyrazines N-substituted imidazoles Imidolactams Heteroaromatic compounds Ureas Azacyclic compounds Primary amines Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Trifluoromethylbenzene - N-phenylurea - Naphthalene - Imidazo[1,5-a]pyrazine - Aminopyrazine - Monocyclic benzene moiety - Imidolactam - Pyrazine - N-substituted imidazole - Azole - Imidazole - Heteroaromatic compound - Urea - Azacycle - Organoheterocyclic compound - Alkyl fluoride - Organofluoride - Organohalogen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Amine - Alkyl halide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	5.531
hba_count	3
HBD Count	3
Rotatable Bond	5

Names and Identifiers

Pubchem Sid	504772329
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772329
IUPAC Name	1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
INCHI	InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)
InChIKey	NOHQEAFAESMMDX-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
Isomeric SMILES	CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
Molecular Weight	518.53
Reaxy-Rn	29115164
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29115164&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
I2207820	Certificate of Analysis	Jun 10, 2025	K414099
I2207818	Certificate of Analysis	Jun 10, 2025	K414099
I2207819	Certificate of Analysis	Jun 10, 2025	K414099
J2231141	Certificate of Analysis	Jul 05, 2022	K414099

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 60 mg/mL (115.71 mM); Ethanol: 60 mg/mL (115.71 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	60
DMSO(mM) Max Solubility	115.7117235
Water(mg / mL) Max Solubility	＜1
Molecular Weight	518.500 g/mol
XLogP3	6.500
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	518.204 Da
Monoisotopic Mass	518.204 Da
Topological Polar Surface Area	97.300 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	834.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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