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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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K274698-1mg
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1mg |
2
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$71.90
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K274698-5mg
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5mg |
2
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$296.90
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Cell-permeable, potent, selective class I α-mannosidase inhibitor
| Synonyms | FR-900494 | (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Cell-permeable, potent, selective inhibitor of class I α-mannosidases. (IC 50 = 20-50 nM for\xa0mung bean α-1,2-mannosidase I). Alkaloid originally isolated from the actinomycete Kitasatosporia kifunense . Used to suppress Endoplasmic Reticulum-Associated |
| Storage Temp | Store at -20°C,Desiccated |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives |
| Direct Parent | Alpha amino acids and derivatives |
| Alternative Parents | Imidazopyridines Piperidines Imidazolidinones Tertiary carboxylic acid amides Secondary carboxylic acid amides Secondary alcohols Lactams Polyols Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Alpha-amino acid or derivatives - Imidazopyridine - Imidazolidinone - Piperidine - Imidazolidine - Tertiary carboxylic acid amide - Carboxamide group - Lactam - Secondary carboxylic acid amide - Secondary alcohol - Azacycle - Organoheterocyclic compound - Polyol - Organooxygen compound - Organonitrogen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Primary alcohol - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. |
| External Descriptors | Not available |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504757004 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504757004 |
| IUPAC Name | (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)-1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-2,3-dione |
| INCHI | InChI=1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1 |
| InChIKey | OIURYJWYVIAOCW-PQMKYFCFSA-N |
| Smiles | C(C1C(C(C(C2N1C(=O)C(=O)N2)O)O)O)O |
| Isomeric SMILES | C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H]2N1C(=O)C(=O)N2)O)O)O)O |
| Molecular Weight | 232.19 |
| Reaxy-Rn | 38226983 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38226983&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 11, 2025 | K274698 | |
| Certificate of Analysis | Jun 11, 2025 | K274698 | |
| Certificate of Analysis | Nov 07, 2024 | K274698 | |
| Certificate of Analysis | Apr 07, 2024 | K274698 | |
| Certificate of Analysis | Apr 07, 2024 | K274698 | |
| Certificate of Analysis | Aug 26, 2022 | K274698 | |
| Certificate of Analysis | Aug 26, 2022 | K274698 | |
| Certificate of Analysis | Jan 26, 2022 | K274698 | |
| Certificate of Analysis | Jan 26, 2022 | K274698 |
| Solubility | Soluble in water to 10 mM (with warming) |
|---|---|
| Melt Point(°C) | >208°C (dec.) |
| Molecular Weight | 232.190 g/mol |
| XLogP3 | -2.800 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 1 |
| Exact Mass | 232.07 Da |
| Monoisotopic Mass | 232.07 Da |
| Topological Polar Surface Area | 130.000 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 334.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xue Zhichao, Zeng Jiaming, Yin Xinchi, Li Yongshu, Meng Bo, Zhao Yang, Fang Xiang, Gong Xiaoyun, Dai Xinhua. (2023) Investigation on acquired palbociclib resistance by LC-MS based multi-omics analysis. Frontiers in Molecular Biosciences, 10 |