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KIF18A-IN-2 - 99%, high purity , CAS No.2600559-20-2

COA

Grade & Purity:

≥99%

Cas Number: 2600559-20-2
Molecular Weight: 534.69

In stock

Item Number

K650516

Grouped product items
SKU	Size	Availability	Price	Qty
K650516-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$590.90
K650516-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$890.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	KIF18A-IN-2 is a potent KIF18A inhibitor ( IC 50 =28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	KIF18A-IN-2 is a potent KIF18A inhibitor ( IC 50 =28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer In Vivo KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours . Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice . IP (100 mg/kg) C max (μM) 12.6 AUC 0-24 (μM·h) 147 C 24h (μM) 2.9 PPB (f u ) 0.007 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells) Dosage: 100 mg/kg Administration: i.p., single Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours. Form:Solid IC50& Target:IC 50 : 28 nM (KIF18A)

Names and Identifiers

Smiles	O=C(C1=CC=C(NS(C)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(NC(C)(C)C)(=O)=O)=C4
Molecular Weight	534.69

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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