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Metabolic Enzyme/Protease
MAGL
JZP 430 - ≥98%(HPLC), high purity , CAS No.1672691-74-5

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JZP 430 - ≥98%(HPLC), high purity , CAS No.1672691-74-5

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 1672691-74-5
Molecular Weight: 354.47
PubChem CID: 121513897
PubChem SID: 504772958

In stock

Item Number

J287504

Grouped product items
SKU	Size	Availability	Price
J287504-10mg	10mg	2	$239.90
J287504-25mg	25mg	1	$479.90
J287504-50mg	50mg	1	$769.90
J287504-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,269.90

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

View related series

Lipid metabolism (1912) MAGL (32) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ylN-cyclooctyl-N-methylcarbamate
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and irreversibleα/β-hydrolase domain 6 (ABHD6) inhibitor (IC50= 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Class Organonitrogen compounds
    - Subclass Amines
      - Level5 Tertiary amines
        Level6 Tertiary alkylarylamines
        Level7 Dialkylarylamines

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Class	Organonitrogen compounds
Subclass	Amines
Intermediate Tree Nodes	Tertiary amines - Tertiary alkylarylamines
Direct Parent	Dialkylarylamines
Alternative Parents	Morpholines Imidolactams Thiadiazoles Heteroaromatic compounds Carbamate esters Organic carbonic acids and derivatives Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Dialkylarylamine - Morpholine - Oxazinane - Imidolactam - Azole - Thiadiazole - Carbamic acid ester - Heteroaromatic compound - Carbonic acid derivative - Organoheterocyclic compound - Ether - Azacycle - Oxacycle - Dialkyl ether - Organic oxide - Carbonyl group - Organopnictogen compound - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ABHD6 Tchem Monoacylglycerol lipase ABHD6 (6 Activities)

Discover Target: ABHD6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGLL Tchem Monoglyceride lipase (1909 Activities)

Discover Target: MGLL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504772958
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772958
IUPAC Name	(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl) N-cyclooctyl-N-methylcarbamate
INCHI	InChI=1S/C16H26N4O3S/c1-19(13-7-5-3-2-4-6-8-13)16(21)23-15-14(17-24-18-15)20-9-11-22-12-10-20/h13H,2-12H2,1H3
InChIKey	WKSHMJCYWFOADB-UHFFFAOYSA-N
Smiles	CN(C1CCCCCCC1)C(=O)OC2=NSN=C2N3CCOCC3
Isomeric SMILES	CN(C1CCCCCCC1)C(=O)OC2=NSN=C2N3CCOCC3
Molecular Weight	354.47
Reaxy-Rn	27868603
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27868603&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
L2304238	Certificate of Analysis	Nov 20, 2023	J287504
L2304239	Certificate of Analysis	Nov 20, 2023	J287504
L2304287	Certificate of Analysis	Nov 20, 2023	J287504
L2304240	Certificate of Analysis	Nov 20, 2023	J287504
L2304244	Certificate of Analysis	Nov 20, 2023	J287504
L2304246	Certificate of Analysis	Nov 20, 2023	J287504
L2304247	Certificate of Analysis	Nov 20, 2023	J287504

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 17.72, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 7.09, Max Conc. mM: 20
Molecular Weight	354.500 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	354.173 Da
Monoisotopic Mass	354.173 Da
Topological Polar Surface Area	96.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	401.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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