JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

This is a demo store. No orders will be fulfilled.

Account

Settings

Language

྾

Home
Small Molecules & Compound Libraries
Signaling Pathways
Metabolic Enzyme/Protease
MMP
JNJ 0966 - ≥98%(HPLC), high purity , CAS No.315705-75-0

Skip to the end of the images gallery

Skip to the beginning of the images gallery

JNJ 0966 - ≥98%(HPLC), high purity , CAS No.315705-75-0

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 315705-75-0
Molecular Weight: 360.45
PubChem CID: 1117189
PubChem SID: 488191718

In stock

Item Number

J287020

Grouped product items
SKU	Size	Availability	Price
J287020-5mg	5mg	2	$117.90
J287020-10mg	10mg	2	$177.90
J287020-25mg	25mg	2	$385.90
J287020-50mg	50mg	2	$692.90
J287020-100mg	100mg	2	$1,236.90

Pro-MMP9 activation inhibitor

View related series

Amino Acid/Protein Metabolism (1836) Metabolic Enzyme/Protease (4860) MMP (148)

Basic Description

Synonyms	N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide \| JNJ0966 \| N-[2-[(2-Methoxyphenyl)amino]-4′-methyl[4,5′-bithiazol]-2′-yl]acetamide
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Pro-MMP9 activation inhibitor (IC50= 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion inin vitroassays. Reduce
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Class Organonitrogen compounds
    - Subclass N-arylamides

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Class	Organonitrogen compounds
Subclass	N-arylamides
Intermediate Tree Nodes	Not available
Direct Parent	N-acetylarylamines
Alternative Parents	Methoxyanilines 2,4,5-trisubstituted thiazoles Phenoxy compounds Methoxybenzenes Anisoles 2,4-disubstituted thiazoles Alkyl aryl ethers 2-amino-1,3-thiazoles Acetamides Heteroaromatic compounds Amino acids and derivatives Secondary carboxylic acid amides Azacyclic compounds Secondary amines Hydrocarbon derivatives Organic oxides Organopnictogen compounds Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	N-acetylarylamine - Methoxyaniline - Phenoxy compound - 2,4,5-trisubstituted 1,3-thiazole - Anisole - Phenol ether - Aniline or substituted anilines - Methoxybenzene - 2,4-disubstituted 1,3-thiazole - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - 1,3-thiazol-2-amine - Acetamide - Thiazole - Azole - Heteroaromatic compound - Amino acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Organoheterocyclic compound - Secondary amine - Carboxylic acid derivative - Ether - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organooxygen compound - Amine - Organopnictogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as n-acetylarylamines. These are acetamides where one or more amide hydrogens is substituted by an aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MMP9 Tchem Matrix metalloproteinase-9 (1 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HT-1080 (3966 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488191718
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488191718
IUPAC Name	N-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
INCHI	InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)
InChIKey	ZADCDCMLLGDCRM-UHFFFAOYSA-N
Smiles	CC1=C(SC(=N1)NC(=O)C)C2=CSC(=N2)NC3=CC=CC=C3OC
Isomeric SMILES	CC1=C(SC(=N1)NC(=O)C)C2=CSC(=N2)NC3=CC=CC=C3OC
Molecular Weight	360.45
Reaxy-Rn	12373585
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12373585&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
B2327869	Certificate of Analysis	Aug 29, 2022	J287020
B2327872	Certificate of Analysis	Aug 29, 2022	J287020
B2327891	Certificate of Analysis	Aug 29, 2022	J287020
B2327877	Certificate of Analysis	Aug 29, 2022	J287020
B2327870	Certificate of Analysis	Aug 29, 2022	J287020
B2327884	Certificate of Analysis	Aug 29, 2022	J287020
B2327871	Certificate of Analysis	Aug 29, 2022	J287020
B2327868	Certificate of Analysis	Aug 29, 2022	J287020
B2327863	Certificate of Analysis	Aug 29, 2022	J287020
B2327883	Certificate of Analysis	Aug 29, 2022	J287020

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 18.02, Max Conc. mM: 50
Molecular Weight	360.500 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	360.071 Da
Monoisotopic Mass	360.071 Da
Topological Polar Surface Area	133.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	442.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.