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JKE-1716 - ≥98.0%, high purity , CAS No.2421118-05-8

COA

Grade & Purity:

≥98%

Cas Number: 2421118-05-8
Molecular Weight: 451.30
PubChem CID: 145865953

In stock

Item Number

J647661

Grouped product items
SKU	Size	Availability	Price	Qty
J647661-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$170.90
J647661-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$390.90

View related series

Apoptosis (4276) Ferroptosis (356) Glucose Metabolism (1943) Glutathione Peroxidase (23) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition In Vitro JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability. JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: LOX-IMVI cells Concentration: 0~100 nΜ Incubation Time: 72 hours Result: Inhibited cell viability. Form:Solid IC50& Target:GPX4, ,Ferroptosis

Names and Identifiers

IUPAC Name	(3Z)-1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-3-hydroxyimino-3-nitropropan-1-one
INCHI	InChI=1S/C20H20Cl2N4O4/c21-16-5-1-14(2-6-16)20(15-3-7-17(22)8-4-15)25-11-9-24(10-12-25)19(27)13-18(23-28)26(29)30/h1-8,20,28H,9-13H2/b23-18-
InChIKey	HZFRTZXJNACSIE-NKFKGCMQSA-N
Smiles	C1CN(CCN1C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C(=O)CC(=NO)[N+](=O)[O-]
PubChem CID	145865953
Molecular Weight	451.30

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