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JHU-083 - 99%, high purity , CAS No.1998725-11-3

COA

Grade & Purity:

≥99%

Cas Number: 1998725-11-3
Molecular Weight: 312.36
PubChem CID: 137283416

In stock

Item Number

J414248

Grouped product items
SKU	Size	Availability	Price	Qty
J414248-2mg	2mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
J414248-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$559.90

Glutaminase Antagonists

View related series

Amino Acid/Protein Metabolism (1836) Glutaminase (27) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	Ethyl 2-(2-Amino-4-methylpentanamido)-DONL-Norleucine,L-leucyl-6-diazo-5-oxo-,ethyl ester
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b⁺ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions a
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information JHU-083 JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b + cells and prevents depression-associated behaviors induced by chronic social defeat stress. Solutions are best fresh-prepared. Targets Glutaminase In vitro JHU-083 selectively inhibits T-cell proliferation and decreases T-cell activation, with no eﬀect on DCs. In vivo orally administered JHU-083 significantly decreases the experimental autoimmune encephalomyelitis(EAE) severity in both prevention and treatment paradigms and reverses EAE-induced cognitive impairment. Cell Research(from reference) Cell lines：CD4⁺ T cells Concentrations：1 μM, 3 μM, 10 μM, 30 μM, or 100 μM Incubation Time：72h

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate
INCHI	InChI=1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1
InChIKey	YZRCHOFKIPHQBW-RYUDHWBXSA-N
Smiles	CCOC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC(C)C)N
Isomeric SMILES	CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@H](CC(C)C)N
Molecular Weight	312.36
Reaxy-Rn	29866752
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29866752&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 62 mg/mL (198.48 mM); Water: 62 mg/mL (198.48 mM); Ethanol: 62 mg/mL (198.48 mM);

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