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JC124 - 10mM in DMSO, high purity , CAS No.1638611-48-9(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1638611-48-9(DMSO)
Molecular Weight: 382.86

In stock

Item Number

J656281

Grouped product items
SKU	Size	Availability	Price	Qty
J656281-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$330.90

View related series

Compound libraries (12325) Immunology/Inflammation (1929) NOD-like Receptor (NLR) (55)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects. In Vitro JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI) Dosage: 100 mg/kg Administration: i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI Result: Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.

Names and Identifiers

Smiles	O=C(C1=CC(Cl)=CC=C1OC)NCCC2=CC=C(C=C2)S(=O)(NC)=O
Molecular Weight	382.86

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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