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IU1 - 98% (HPLC), high purity , CAS No.314245-33-5, Inhibitor of ubiquitin specific peptidase 14

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 314245-33-5
Molecular Weight: 300.37
PubChem CID: 675434
PubChem SID: 488191043

In stock

Item Number

I169504

Grouped product items
SKU	Size	Availability	Price
I169504-5mg	5mg	3	$64.90
I169504-10mg	10mg	2	$90.90
I169504-25mg	25mg	1	$204.90
I169504-50mg	50mg	1	$299.90
I169504-100mg	100mg	1	$534.90
I169504-200mg	200mg	1	$963.90

Selective, reversible Usp14 inhibitor. Cell-permeable

View related series

Autophagy (1917) Cell Cycle/DNA Damage (2602) Deubiquitinase (86) ubiquitin specific peptidase 14 Inhibitor (3) Unfolded Protein Response (214)

Basic Description

Synonyms	BDBM50437694 \| HMS2742M13 \| Usp14 inhibitor \| AMY24153 \| NCGC00249377-08 \| HMS3743A07 \| EN300-72884 \| MFCD01917473 \| SR-01000010584 \| 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone \| SCHEMBL6923146 \| EX-A2079 \| MLS001032847
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective, reversible Usp14 inhibitor (IC 50 = 4 μM). Enhances degradation of proteasome substrates. Reduces rate of ubiquitin chain trimming bound to cyclin B or other ubiquitin chains. Active in vitro . Cell-permeable.IU1 is an inhibitor of USP14, a deu
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ubiquitin specific peptidase 14
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	IU1 is a special Usp14 inhibitor with an IC50 of 4-5 μM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrroles
    - Subclass Substituted pyrroles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrroles
Subclass	Substituted pyrroles
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyrroles
Alternative Parents	Aryl alkyl ketones Fluorobenzenes N-alkylpyrrolidines Aryl fluorides Vinylogous amides Heteroaromatic compounds Alpha-amino ketones Trialkylamines Azacyclic compounds Organopnictogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	1-phenylpyrrole - Aryl alkyl ketone - Aryl ketone - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - N-alkylpyrrolidine - Benzenoid - Alpha-aminoketone - Heteroaromatic compound - Pyrrolidine - Vinylogous amide - Ketone - Tertiary amine - Tertiary aliphatic amine - Azacycle - Amine - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyrroles. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrole ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

USP14 Tchem Ubiquitin carboxyl-terminal hydrolase 14 (1 Activities)

Discover Target: USP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP5 Tchem Ubiquitin carboxyl-terminal hydrolase 5 (172 Activities)

Discover Target: USP5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP14 Tchem Ubiquitin carboxyl-terminal hydrolase 14 (35 Activities)

Discover Target: USP14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488191043
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488191043
IUPAC Name	1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
INCHI	InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
InChIKey	JUWDSDKJBMFLHE-UHFFFAOYSA-N
Smiles	CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
Isomeric SMILES	CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
WGK Germany	3
Molecular Weight	300.37
Reaxy-Rn	21391902
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21391902&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
C23161191	Certificate of Analysis	Dec 13, 2022	I169504
C23161171	Certificate of Analysis	Dec 13, 2022	I169504
C23161172	Certificate of Analysis	Dec 13, 2022	I169504
C23161016	Certificate of Analysis	Dec 13, 2022	I169504
C23161173	Certificate of Analysis	Dec 13, 2022	I169504
C23161055	Certificate of Analysis	Dec 13, 2022	I169504
C2316961	Certificate of Analysis	Dec 13, 2022	I169504
C2316821	Certificate of Analysis	Dec 13, 2022	I169504
C2316822	Certificate of Analysis	Dec 13, 2022	I169504
C2316829	Certificate of Analysis	Dec 13, 2022	I169504
C2316823	Certificate of Analysis	Dec 13, 2022	I169504
C2316830	Certificate of Analysis	Dec 13, 2022	I169504

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Chemical and Physical Properties

Molecular Weight	300.400 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	300.164 Da
Monoisotopic Mass	300.164 Da
Topological Polar Surface Area	25.200 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	389.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Alternative Products

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