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Isosorbide - 10mM in DMSO, high purity , CAS No.652-67-5

    Grade & Purity:
  • 10mM in DMSO
In stock
Item Number
I425302
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Price Qty
I425302-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90

Osmotic diuretic agent

View related series
Compound libraries (12325)

Basic Description

Synonyms isosorbide | 652-67-5 | Isobide | Devicoran | Hydronol | Ismotic | Sorbid | (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol | (+)-D-Isosorbide | 1,4:3,6-Dianhydro-D-glucitol | 1,4-Dianhydrosorbitol | Vascardin dinitrate | Dianhydro-D-glucitol | D-Glucitol, 1,4:3,6-dianhydro- | AT
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms Osmotic diuretic agent. Nitric oxide donor. Shows vasodilatory, antihypertensive and diuretic effects in vivo. Orally active.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Furofurans
Subclass Isosorbides
Intermediate Tree Nodes Not available
Direct Parent Isosorbides
Alternative Parents Tetrahydrofurans  Secondary alcohols  Oxacyclic compounds  Dialkyl ethers  Hydrocarbon derivatives  
Molecular Framework Aliphatic heteropolycyclic compounds
Substituents Isosorbide - Tetrahydrofuran - Secondary alcohol - Oxacycle - Ether - Dialkyl ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Alcohol - Aliphatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as isosorbides. These are organic polycyclic compounds containing an isosorbide(1,4-Dianhydrosorbitol) moiety, which consists of two -oxolan-3-ol rings.
External Descriptors Not available

Associated Targets(Human)

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
INCHI InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey KLDXJTOLSGUMSJ-JGWLITMVSA-N
Smiles C1C(C2C(O1)C(CO2)O)O
Isomeric SMILES C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O
WGK Germany 2
RTECS LZ4380000
Molecular Weight 146.14
Beilstein 80510
Reaxy-Rn 80508
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=80508&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity Moisture sensitive
Specific Rotation[α] 45° (C=5,H2O)
Boil Point(°C) 175°C/2mmHg
Melt Point(°C) 58-63℃
Molecular Weight 146.140 g/mol
XLogP3 -1.400
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 0
Exact Mass 146.058 Da
Monoisotopic Mass 146.058 Da
Topological Polar Surface Area 58.900 Ų
Heavy Atom Count 10
Formal Charge 0
Complexity 122.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Fukai Chu, Wei Wang, Yifan Zhou, Zhoumei Xu, Bin Zou, Xin Jiang, Yandong Hu, Weizhao Hu.  (2023)  Fully bio-based and intrinsically flame retardant unsaturated polyester cross-linked with isosorbide-based diluents.  CHEMOSPHERE,  344  (140371). 
2. Feng Caixing, Ma Haihong, Ren Fengmei, Zhou Zhengfa, Xu Weibing.  (2023)  Synthesis of fully bio-based branched unsaturated polyester oligomers and UV curing coatings.  Journal of Coatings Technology and Research,  20  (5): (1747-1758). 
3. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao.  (2023)  Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide.  CHEMICAL ENGINEERING JOURNAL,  460  (141780). 
4. Jiaying Gu, Ming Liu, Lin Li, Lulu Zhou, Lei He, Weijun Deng, Jing Hu.  (2023)  Osmanthus fragrance polyurethane/silk fibroin-based double-shell microcapsules for aromatic leather with sustained release fragrance.  FLAVOUR AND FRAGRANCE JOURNAL,  38  (2): (73-82). 
5. Yinglu Sun, Xinxin Tian, Haopu Xie, Biru Shi, Jiahui Zhong, Xiangdong Liu, Yuming Yang.  (2022)  Reprocessable and degradable bio-based polyurethane by molecular design engineering with extraordinary mechanical properties for recycling carbon fiber.  POLYMER,  258  (125313). 
6. Yong Li, Jiehao Qu, Zenghui Dai, Junyi Jiang, Jiajia Fu, Feiya Fu, Xiangdong Liu.  (2022)  Highly Bio-Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer.  MACROMOLECULAR MATERIALS AND ENGINEERING,  307  (9): (2200203). 
7. Xin Wang, Haoxin Niu, Wenwen Guo, Lei Song, Yuan Hu.  (2021)  Renewable isosorbide-derived poly(phosphoester) for simultaneously enhanced flame-retardancy and mechanical property of polylactide.  Progress in Natural Science-Materials International,  31  (546). 
8. Yuchao Wu, Mingen Fei, Tingting Chen, Renhui Qiu, Wendi Liu.  (2021)  Fabrication of degradable and high glass-transition temperature thermosets from palm oil and isosorbide for fiber-reinforced composites.  INDUSTRIAL CROPS AND PRODUCTS,  170  (113744). 
9. Weiwei Wang, Zifeng Yang, Yaqin Zhang, Hongyan He, Wenjuan Fang, Zhencai Zhang, Fei Xu.  (2021)  A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains.  GREEN CHEMISTRY,  23  (11): (4134-4143). 
10. Xiaodong Liu, Xiaohao Liu, Ning Li, Peiyong Ma, Ying Zhang.  (2021)  Direct synthesis of hexitols from microcrystalline cellulose and birch over zirconium(IV) phosphate supported nickel catalysts and the mechanism study.  GREEN CHEMISTRY,  23  (3): (1353-1360). 
11. Zifeng Yang, Lei Liu, Hongzhe An, Chenhao Li, Zhencai Zhang, Wenjuan Fang, Fei Xu, Suojiang Zhang.  (2020)  Cost-Effective Synthesis of High Molecular Weight Biobased Polycarbonate via Melt Polymerization of Isosorbide and Dimethyl Carbonate.  ACS Sustainable Chemistry & Engineering,  (27): (9968–9979). 
12. Lele Jin, Wenzhi Li, Qiying Liu, Longlong Ma, Chao Hu, Ajibola T. Ogunbiyi, Mingwei Wu, Qi Zhang.  (2020)  High performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes.  BIORESOURCE TECHNOLOGY,  297  (122492). 
13. Wanming Wang, Feng Wu, Huanjun Lu, Xiaohong Li, Xiaoming Yang, Yingfeng Tu.  (2019)  A Cascade Polymerization Method for the Property Modification of Poly(butylene terephthalate) by the Incorporation of Isosorbide.  ACS Applied Polymer Materials,  (9): (2313–2321). 
14. Danping Yuan, Ning Zhao, Yanxia Wang, Keng Xuan, Feng Li, Yanfeng Pu, Feng Wang, Lei Li, Fukui Xiao.  (2019)  Dehydration of sorbitol to isosorbide over hydrophobic polymer-based solid acid.  APPLIED CATALYSIS B-ENVIRONMENTAL,  240  (182). 
15. Xinyi Gao, Jie Jiang, Junyao Shen, Shaoliang Lin, Ling Zhao, Zhenhao Xi.  (2024)  Alkali Metal/Quaternary Ammonium Salt Synergistic Catalytic System for the Efficient Synthesis of Biobased Poly(Isosorbide Carbonate).  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,  63  (23): (10192-10202). 
16. Yujia Xie, Hailin Zhuang, Weibing Pei, Jiaming Guo, Yan Ma, Lingqiang Kong, Yuhui Ao, Liu Liu, Yu Liu.  (2024)  Bio-based semi-aromatic waterborne PIEK-C sizing agent to construct a robust interface for CF/PEEK composites.  POLYMER COMPOSITES,     
17. Yuehong Zhang, Qinyang Lei, Shutong Zhang, Langlang Dai, Bin Lyu, Leipeng Liu.  (2024)  Biobased Unsaturated Polyester Thermosets from Castor Oil and Isosorbide with Life Cycle Assessment.  ACS Sustainable Chemistry & Engineering,  13  (1): (374-385). 
18. Dan Li, Youbing Li, Yu Zhang, Yunsheng Xu, Xianming Zhang, Minna Hakkarainen.  (2025)  Designing Biobased Poly(ethylene-co-isosorbide terephthalate) Copolyesters with Tunable Properties and Degradability.  BIOMACROMOLECULES,     
19. Dechang Cheng, Zhihong Ma, Ziyang Liu, Xiaohui Liu, Tao Liu, Weizhen Sun, Ling Zhao.  (2024)  Experiments and kinetic modeling of the sorbitol dehydration to isosorbide catalyzed by sulfuric acid under conditions of non-constant volume.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,     
20. Yiwen Zhang, Chenhao Li, Hao Wang, Zhao Yang, Wentao Zhang, Zhencai Zhang, Ruixia Liu, Fei Xu.  (2024)  Facile fabrication of hemicrystalline bio-based polycarbonate with superhydrophobic and high transmittance.  POLYMER,  313  (127729). 
21. Xindi Feng, Dian Jin, Youcai Zhu, Jiale Peng, Yue Mu, Li Sun, Zuoxiang Zeng, Zhen Liu.  (2024)  Insights into the Role of Deep Eutectic Solvents in Sorbitol Dehydration: A Combined Experimental and Molecular Dynamics Study.  ACS Sustainable Chemistry & Engineering,  12  (46): (17035-17043). 
22. Shimin Geng, Zhen Huang, Yizhen Chen, Ying Li, Liyuan Zhang, Mingen Fei, Renhui Qiu, Wendi Liu.  (2024)  Polyurethane Acrylate Covalent Adaptable Networks Based on the Autocatalytic Effect of Palm Oil-Based Diol.  ACS Applied Polymer Materials,  (23): (14760-14771). 
23. Yilin Shi, Jinhai Yang, Jiong Guo, Shiwei Wang, Danping Yuan, Ning Zhao, Fukui Xiao, Jianfeng Gao.  (2024)  Preparation of isosorbide by dehydration of sorbitol on hierarchical Beta zeolites under solvent-free conditions.  MICROPOROUS AND MESOPOROUS MATERIALS,  368  (113009). 

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