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Metabolism
Isoliquiritigenin - 10mM in DMSO, high purity , CAS No.961-29-5(DMSO)
Isoliquiritigenin - 10mM in DMSO, high purity , CAS No.961-29-5(DMSO)
Aldose Reductase Inhibitors
Basic Description
Synonyms
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Information
Isoliquiritigenin Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.In vitro
Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)).
In vivo
LD50: Mice >6g/kg (i.g.)Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
Associated Targets(Human)
Names and Identifiers
Smiles
OC1=CC=C(C=C1)\C=C\C(=O)C2=C(O)C=C(O)C=C2
Molecular Weight
256.25
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Citations of This Product
1.
Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan.
(2023)
Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
668
(90).
2.
Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu.
(2023)
Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY,
38
(3):
(654-665).
3.
Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu.
(2022)
Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel,
9
(8):
(382).
4.
Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu.
(2021)
Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE,
1241
(130686).
5.
Li-Juan Wang, Lin He, Lu Hao, Hong-Lei Guo, Xiang-Peng Zeng, Ya-Wei Bi, Guo-Tao Lu, Zhao-Shen Li, Liang-Hao Hu.
(2020)
Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,
24
(17):
(9667-9681).
6.
Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.
(2019)
Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods,
8
(9):
(355).
7.
Zhang Man, Wu Yan-Qing, Xie Ling, Wu Jiang, Xu Ke, Xiao Jian, Chen Da-Qing.
(2018)
Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling. Frontiers in Pharmacology,
9
(936).
8.
Jie-hua Shi, Jing Wang, Ying-yao Zhu, Jun Chen.
(2014)
Characterization of interaction between isoliquiritigenin and bovine serum albumin: Spectroscopic and molecular docking methods. JOURNAL OF LUMINESCENCE,
145
(643).
9.
Sisi Ke, Ningrui Wang, Xingyu Chen, Jiangwei Tian, Jiwei Li, Boyang Yu.
(2025)
A Label-Free Colorimetric Aptasensor for Flavokavain B Detection. SENSORS,
25
(2):
(569).
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9 Citations