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ISCK03 - 10mM in DMSO, high purity , CAS No.945526-43-2

COA

Grade & Purity:

10mM in DMSO

Cas Number: 945526-43-2
Molecular Weight: 355.45
PubChem CID: 3792751

In stock

Item Number

I427041

Grouped product items
SKU	Size	Availability	Price	Qty
I427041-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$70.90

Cell-permeable, selective SCF/c-Kit inhibitor

View related series

Compound libraries (12325) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	ISCK03 \| 945526-43-2 \| tert-Butylphenyl imidazolylphenyl sulfonamide \| Stem-Cell Factor/c-Kit Inhibitor, ISCK03 \| Whiteplex-IN \| 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide \| ISCK 03 \| ISCK-03 \| t-Butylphenyl imidazolylphenyl sulfonamide \| t-Butylphenyl imidaz
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Cell-permeable, selective SCF/c-Kit inhibitor (IC 50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo. ISCK03 inhibits in vitr
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Imidazoles
      - Level5 Substituted imidazoles
        Level6 Phenylimidazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Imidazoles
Intermediate Tree Nodes	Substituted imidazoles
Direct Parent	Phenylimidazoles
Alternative Parents	Sulfanilides Benzenesulfonamides Phenylpropanes Benzenesulfonyl compounds Organosulfonamides N-substituted imidazoles Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	1-phenylimidazole - Benzenesulfonamide - Sulfanilide - Benzenesulfonyl group - Phenylpropane - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Organosulfonic acid amide - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Organonitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
INCHI	InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
InChIKey	XQABBHBFHWHMKF-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
Isomeric SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
Molecular Weight	355.45
Reaxy-Rn	11120520
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11120520&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Sensitivity	light sensitive
Molecular Weight	355.500 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	355.135 Da
Monoisotopic Mass	355.135 Da
Topological Polar Surface Area	72.400 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	522.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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