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IQ-1 - 95% (HPLC), high purity , CAS No.331001-62-8

COA

Grade & Purity:

≥95%(HPLC)

Cas Number: 331001-62-8
Molecular Weight: 362.42
PubChem CID: 5721207
PubChem SID: 504763953

In stock

Item Number

I169621

Grouped product items
SKU	Size	Availability	Price
I169621-1mg	1mg	1	$18.90
I169621-5mg	5mg	2	$77.90
I169621-25mg	25mg	1	$234.90
I169621-100mg	100mg	2	$846.90

Cell-permeable Wnt pathway activator

View related series

Stem Cell/Wnt (1019) Wnt (104)

Basic Description

Synonyms	CCG-208080 \| BS-16587 \| 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide \| 2-(2-(4-Acetylphenyl)hydrazono)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)acetamide \| Acetamide,2-[2-(4-acetylphenyl)diazenyl]-2-(3,4
Specifications & Purity	≥95%(HPLC)
Biochemical and Physiological Mechanisms	IQ-1 enhances β-catenin/CBP interactions and blocks β-catenin/p300 driven transcription, which enables mouse embryonic stem cells (ESCs) to be maintained in an undifferentiated pluripotent state, allowing expansion and self-renewal of mouse ESC population
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Q 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - Class Organooxygen compounds
    - Subclass Carbonyl compounds
      - Level5 Ketones
        Level6 Aryl ketones
        Level7 Phenylketones
        Level8 Alkyl-phenylketones

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
Class	Organooxygen compounds
Subclass	Carbonyl compounds
Intermediate Tree Nodes	Ketones - Aryl ketones - Phenylketones
Direct Parent	Alkyl-phenylketones
Alternative Parents	Dihydroisoquinolines Acetophenones Phenylhydrazines Benzoyl derivatives Aryl alkyl ketones Primary carboxylic acid amides Ketimines Propargyl-type 1,3-dipolar organic compounds Hydrazones Azacyclic compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Alkyl-phenylketone - Dihydroisoquinoline - Acetophenone - Benzoyl - Phenylhydrazine - Aryl alkyl ketone - Monocyclic benzene moiety - Benzenoid - Carboxamide group - Ketimine - Primary carboxylic acid amide - Azacycle - Hydrazone - Carboxylic acid derivative - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organonitrogen compound - Imine - Organic oxide - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504763953
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504763953
IUPAC Name	(2Z)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
INCHI	InChI=1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,24H,12H2,1-3H3,(H2,22,27)/b25-19-
InChIKey	ALJIEVIJBAJISI-PLRJNAJWSA-N
Smiles	CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N
Isomeric SMILES	CC(=O)C1=CC=C(C=C1)N/N=C(/C2=NC(CC3=CC=CC=C32)(C)C)\C(=O)N
PubChem CID	5721207
Molecular Weight	362.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
L2412099	Certificate of Analysis	Dec 18, 2024	I169621
H2106102	Certificate of Analysis	May 11, 2024	I169621
H2106097	Certificate of Analysis	May 11, 2024	I169621
H2106098	Certificate of Analysis	May 11, 2024	I169621
H2106099	Certificate of Analysis	May 11, 2024	I169621

Chemical and Physical Properties

Solubility	solubility DMSO: 10 mg/mL, clear;Ethanol :7 mg/mL Insoluble in water
Molecular Weight	362.400 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	362.174 Da
Monoisotopic Mass	362.174 Da
Topological Polar Surface Area	96.900 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	645.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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