Basic Description

Specifications & Purity	UltraBio™
Biochemical and Physiological Mechanisms	Iodoacetamide (IAA) is used to inhibit glycolysis due to its ability to irreversibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). IAA is used to investigate the role of cysteine residues in enzyme catalysis and the brain
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Grade	UltraBio™
Product Description	Iodoacetamide has been used: in protein digestion for proteomic analysis to alkylate protein samples in the denaturation of cow′s milk allergens, β-lactoglobulin (BLG) and α-lactalbumin (ALA)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Carboxylic acid derivatives
      - Level5 Carboxylic acid amides
        Level6 Primary carboxylic acid amides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Carboxylic acid derivatives
Intermediate Tree Nodes	Carboxylic acid amides
Direct Parent	Primary carboxylic acid amides
Alternative Parents	Organopnictogen compounds Organonitrogen compounds Organoiodides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl iodides
Molecular Framework	Aliphatic acyclic compounds
Substituents	Primary carboxylic acid amide - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organoiodide - Organohalogen compound - Carbonyl group - Alkyl iodide - Alkyl halide - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as primary carboxylic acid amides. These are compounds comprising primary carboxylic acid amide functional group, with the general structure RC(=O)NH2.
External Descriptors	an iodide
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	2-iodoacetamide
INCHI	InChI=1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
InChIKey	PGLTVOMIXTUURA-UHFFFAOYSA-N
Smiles	C(C(=O)N)I
Isomeric SMILES	C(C(=O)N)I
WGK Germany	3
RTECS	AC4200000
UN Number	2811
Packing Group	III
Molecular Weight	184.96
Beilstein	1739080
Reaxy-Rn	1739080
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1739080&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	H 2 O: 0.5 M, clear, colorless
Melt Point(°C)	95°C
Molecular Weight	184.960 g/mol
XLogP3	-0.200
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	184.934 Da
Monoisotopic Mass	184.934 Da
Topological Polar Surface Area	43.100 Å²
Heavy Atom Count	5
Formal Charge	0
Complexity	44.900
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Fang Jun-Ting, Wang Si-Tao, Wang Haibin, Fang Wei-Jie. (2025) A Novel Peptide Mapping Method Utilizing Cysteine as a Reducing Agent. PHARMACEUTICAL RESEARCH, 42 (1): (173-184).
2. Yu-Jie Shi, Fan- Gong, Chang-Ying Hu, Zhi-Wei Wang, Jun-Peng Hu, Yan-Ping Xian. (2025) Binding mechanism and safety assessment of BADGE from epoxy-coated cans and protein. FOOD CHEMISTRY, 476 (143347).
3. Zhuo Mi, Wenkang Zhang, Han Wang, Xingyi Qi, Shuo Wang, Jiayi Song, Ping Su, Yi Yang. (2025) Chitosan functionalized two-dimensional covalent organic framework nanosheets with high hydrophilicity for efficient glycopeptide enrichment. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, (124461).
4. Huize Jiang, Jinge Yang, Aihong Wang, Yuzhi li, Jinyu Wang, Kaibo Wang. (2025) Construction of multi-transition metal sulphides and its superiority for degradation of carbamazepine by activation of peroxymonosulfate. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 704 (135444).
5. Li Wang, Meng Zhang, Yufei Shu, Qi Han, Li Long, Beizhao Chen, Mengxia Wang, Li Li, Siyu Cao, Zhe Yang, Bei Liu, Zhongying Wang, Chuyang Y. Tang. (2024) Covalently modified MoS2 for the fabrication of interlayered thin film composite membranes with excellent structural stability against swelling and drying in organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 707 (122985).
6. Xuemeng Ji, Aiying Shi, Jin Wang, Bowei Zhang, Yaozhong Hu, Huan Lv, Jing Wu, Yi Sun, Jing-Min Liu, Yan Zhang, Shuo Wang. (2024) EnvZ/OmpR Controls Protein Expression and Modifications in Cronobacter sakazakii for Virulence and Environmental Resilience. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72 (33): (18697-18707).
7. Chao He, Xiuyuan Chen, Ying Chen, Jianying Sun, Manting Qi, Sonia Rocha, Mu Wang. (2024) Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA. PROTEOMICS, (2300393).
8. Chenyu Xiao, Qianru Li, Meiqi Li, Yongshu Han, Hubin Xu, Haimin Jiang, Suer Zhang, Zhen Jin, Leilei Gao. (2025) Iodoacetamide triggers ovarian dysfunction in mice through TGF-β signaling pathway and apoptosis. TOXICOLOGY LETTERS,
9. Tianxu Liu, Ismail Muhammad Asif, Lichong Liu, Minghui Zhang, Bin Li, Ling Wang. (2024) Laminarin ameliorates iodoacetamide-induced functional dyspepsia via modulation of 5-HT3 receptors and the gut microbiota. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 268 (131640).
10. Xu Mingming, Liu Zhaoliang, Hu Wenhua, Han Ying, Wu Zhen, Chen Sufeng, Xia Peng, Du Jing, Zhang Xumin, Hao Piliang, Xia Jun, Yang Shuang. (2024) Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas. Journal of Zhejiang University-SCIENCE B, 25 (1): (51-64).
11. Shuang Yue, Xiaotong Wang, Lei Wang, Jiajia Li, Yufeng Zhou, Yan Chen, Zeyang Zhou, Xiaodong Yang, Xiaofeng Shi, Song Gao, Zhongmin Wen, Xiaojun Zhu, Yan Wang, Shuang Yang. (2024) MOTAI: A Novel Method for the Study of O-GalNAcylation and Complex O-Glycosylation in Cancer. ANALYTICAL CHEMISTRY, 96 (28): (11137-11145).
12. Xue Juan, Meng Kun, Lv Jun, Liu Lanfang, Duan Fangfang, Ji Xuemeng, Ding Li. (2025) NlpD as a crucial factor in desiccation resistance and biofilm formation in Cronobacter sakazakii. Scientific Reports, 15 (1): (1-13).
13. Cheng Li, Yu Lu, Zhijun Zhang, Linjuan Huang, Zhongfu Wang. (2025) Online PGC–LC–MS analysis of colonic mucin O-glycans in ovalbumin-induced food allergy in Balb/c mice by treatment with sea cucumber chondroitin sulfate polysaccharide. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 307 (141808).
14. Caiping Zhang, Yimin Zhang, Binjie Liu, Yongxv Chen, Yue Xie, Huiting Huang, Zhongqiu Liu, Zhuoru He. (2024) Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency. JOURNAL OF PROTEOME RESEARCH, 23 (10): (4538-4552).
15. Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X. Chris Le, Qiuquan Wang, Xiaowen Yan. (2024) Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. JOURNAL OF MEDICINAL CHEMISTRY, 67 (7): (5458-5472).
16. Xiaolan Mai, Yu Hu, Zhenlin Wu, Xin Guo, Mingming Dong, Lingyun Jia, Jun Ren. (2024) Self-Assembly of Human Fibrinogen into Microclot-Mimicking Antifibrinolytic Amyloid Fibrinogen Particles. ACS Applied Bio Materials, 8 (1): (825-834).
17. Xin Peng, Xin Huang, Shaolu Zhang, Naixin Zhang, Shengfan Huang, Yingying Wang, Zhenxing Zhong, Shan Zhu, Haiwang Gao, Zixiang Yu, Xiaotong Yan, Zhennan Tao, Yuxiang Dai, Zhe Zhang, Xi Chen, Feng Wang, Francois X. Claret, Moshe Elkabets, Ning Ji, Yuxu Zhong, Dexin Kong. (2024) Sequential Inhibition of PARP and BET as a Rational Therapeutic Strategy for Glioblastoma. Advanced Science, (2307747).
18. Yong Chen, An Liu. (2025) Skin-whitening effect of hydroxypropyl-β-cyclodextrin/glabridin inclusion complex loaded on a dual thermo/pH-sensitive hydrogel. POLYMER, 316 (127788).
19. Lang Ren, Xingqiu Ruan, Hanlin Dong, Yiyao Cheng, Kinyu Shon, Cheng Chang, Renjun Gu, Zhiguang Sun. (2025) The bitter flavor of Banxia Xiexin decoction activates TAS2R38 to ameliorate low-grade inflammation in the duodenum of mice with functional dyspepsia. JOURNAL OF ETHNOPHARMACOLOGY, 341 (119309).
20. Aidi Gao, Chao He, Hengrui Chen, Qianlin Liu, Yin Chen, Jianying Sun, Chuanfeng Wu, Ya Pan, Sonia Rocha, Mu Wang, Jundong Zhou. (2024) TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance. Proteomics Clinical Applications, (e202400010).

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SKU	Size	Availability	Price
I755753-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
I755753-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$270.90
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Iodoacetamide - UltraBio™, high purity , CAS No.144-48-9