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Inter Alpha Inhibitor Proteins (IaIp), Human Plasma

COA

Grade & Purity:

≥90%(SDS-PAGE)

In stock

Item Number

np001052

Grouped product items
SKU	Size	Availability	Price	Qty
np001052-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
np001052-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,600.90

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Enzymes & Inhibitors (30)

Basic Description

Product Name	Inter Alpha Inhibitor Proteins (IaIp), Human Plasma
Product Description	Inter Alpha Inhibitor Proteins (IaIp)- include Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (Pal), with molecular weights of 225 kDa and 125 kDa respectively. Together these proteins are present in plasma at a concentration of approximately 50 mg/100 ml. The inhibitory activity of the proteins is a function of bikunin, the common light chain of the IAIP. In acute inflammation, the lal acts as a negative acute-phase protein, whereas the Pal acts as a positive acute-phase protein. IaIp are being considered as biomarkers and biotherapies for metastatic disease, septic shock and complement system disorders. Activity: Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate. Immunoblotting: Immunoreactive with anti-Bikunin Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. For research use or for use in further manufacturing.
Specifications & Purity	≥90%(SDS-PAGE)
Predicted molecular weight	225,000and125,000Da

Storage and Shipping

Shape	Frozen in 1 x PBS
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Unit definition	Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.

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