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Indotecan - 98%, high purity , CAS No.915303-09-2

COA

Grade & Purity:

≥98%

Cas Number: 915303-09-2
Molecular Weight: 478.49
PubChem CID: 11533060

In stock

Item Number

I412147

Grouped product items
SKU	Size	Availability	Price
I412147-1mg	1mg	3	$39.90
I412147-5mg	5mg	3	$121.90
I412147-10mg	10mg	3	$210.90
I412147-25mg	25mg	3	$376.90
I412147-50mg	50mg	2	$627.90

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Topoisomerase (150) Topoisomerase inhibitor (1)

Basic Description

Synonyms	Indotecan(LMP400) \| LMP400 \| LMP-400 \| LMP400; LMP-400; LMP 400 \| HY-18351 \| 3-[(Morpholine)-1-propyl]-5,3-dimethoxy-8,9-meth ylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline \| AKOS040741879 \| NSC-724998LMP-400 \| UNII-BTA69L5M8D \| BTA69L5M8D \| NSC72499
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Indotecan (LMP-400, NSC-724998) is a potent topoisomerase 1(Top1) inhibitor with IC50 of 300 nM, 1200 nM, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Isoquinolines and derivatives
    - Subclass Isoquinolones and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Isoquinolines and derivatives
Subclass	Isoquinolones and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Isoquinolones and derivatives
Alternative Parents	Benzodioxoles Anisoles Aryl ketones Pyridinones Alkyl aryl ethers Morpholines Vinylogous amides Heteroaromatic compounds Trialkylamines Lactams Oxacyclic compounds Acetals Dialkyl ethers Azacyclic compounds Hydrocarbon derivatives Organic oxides Aldehydes Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Isoquinolone - Benzodioxole - Anisole - Aryl ketone - Alkyl aryl ether - Pyridinone - Morpholine - Oxazinane - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Tertiary amine - Tertiary aliphatic amine - Lactam - Ketone - Azacycle - Oxacycle - Acetal - Dialkyl ether - Ether - Aldehyde - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as isoquinolones and derivatives. These are aromatic polycyclic compounds containing a ketone bearing isoquinoline moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TOP1 Tclin DNA topoisomerase I (7553 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DU-145 (51482 Activities)

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MCF7 (126967 Activities)

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OVCAR-3 (48710 Activities)

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SN12C (47755 Activities)

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UACC-62 (47335 Activities)

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HCT-116 (91556 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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SF-539 (44845 Activities)

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Associated Targets(non-human)

Leishmania infantum (5912 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	15,16-dimethoxy-20-(3-morpholin-4-ylpropyl)-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
INCHI	InChI=1S/C26H26N2O7/c1-31-19-10-15-18(13-20(19)32-2)26(30)28(5-3-4-27-6-8-33-9-7-27)24-16-11-21-22(35-14-34-21)12-17(16)25(29)23(15)24/h10-13H,3-9,14H2,1-2H3
InChIKey	FMFIFGLHVOZDEL-UHFFFAOYSA-N
Smiles	COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6CCOCC6)OC
Isomeric SMILES	COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6CCOCC6)OC
Molecular Weight	478.49
Reaxy-Rn	10618668
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10618668&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
I2404540	Certificate of Analysis	Jun 04, 2024	I412147
I2404536	Certificate of Analysis	Jun 04, 2024	I412147
I2404535	Certificate of Analysis	Jun 04, 2024	I412147
I2404537	Certificate of Analysis	Jun 04, 2024	I412147
I2404538	Certificate of Analysis	Jun 04, 2024	I412147
I2404539	Certificate of Analysis	Jun 04, 2024	I412147
I2404541	Certificate of Analysis	Jun 04, 2024	I412147
I2404564	Certificate of Analysis	Jun 04, 2024	I412147
I2404565	Certificate of Analysis	Jun 04, 2024	I412147
I2404566	Certificate of Analysis	Jun 04, 2024	I412147

Chemical and Physical Properties

Molecular Weight	478.500 g/mol
XLogP3	2.200
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	478.174 Da
Monoisotopic Mass	478.174 Da
Topological Polar Surface Area	86.800 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	872.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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Indotecan - 98%, high purity , CAS No.915303-09-2

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

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