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Indeglitazar - 99%, high purity , Peroxisome proliferator-activated receptor agonist, CAS No.835619-41-5, Peroxisome proliferator-activated receptor agonist

COA

Grade & Purity:

≥98%

Cas Number: 835619-41-5
Molecular Weight: 389.42
PubChem CID: 11395145

In stock

Item Number

I649701

Grouped product items
SKU	Size	Availability	Price
I649701-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9.90
I649701-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$31.90
I649701-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$50.90
I649701-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$101.90
I649701-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$162.90
I649701-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$259.90

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Basic Description

Synonyms	Indeglitazar \| MS-26475 \| INDEGLITAZAR [INN] \| Indeglitazar (USAN) \| AKOS040741878 \| Indeglitazar [USAN] \| 3-[1-(4-Methoxy benzenesulfonyl)-5-methoxy-1H-indol-3-yl]-propionic acid \| YMPALHOKRBVHOJ-UHFFFAOYSA-N \| PLX-204 \| HY-14817 \| PPM 204 \| Q27096942 \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Indeglitazar (PPM 204) is an orally available PPAR pan-agonist for all three PPARα , PPARδ and PPARγ.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	AGONIST
Mechanism of action	Peroxisome proliferator-activated receptor agonist
Product Description	Indeglitazar (PPM 204) is an orally available PPAR pan-agonist for all three PPARα , PPARδ and PPARγ In Vitro In an assay of preadipocyte differentiation, measuring in part functional insulin sensitization capability of the cells, Indeglitazar shows an EC 50 of 0.32 μM compared with Rosiglitazone, which shows an EC 50 of 13 nM, although the maximal response obtained from the 2 compounds is comparable. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo An initial assessment of in vivo activity is carried out using the Zucker rat model of diabetes. The significant lowering of glucose, HbA 1C , triglycerides, and total cholesterol are observed after i.v. treatment with 10 mg/kg Indeglitazar once per day for 3 weeks. Notably, the level of Adiponectin (on day 21) is essentially unchanged in treated vs. untreated animals (4.8 mcg/mL vs. 4.9 mcg/mL), thus the observed reductions in glucose and HbA 1C are achieved in an adiponectin-independent fashion. These differences in the effects of Indeglitazar in vivo may be a consequence of synergy between the 3 PPAR activities or because of the SPPARM profile of the compound, or a combination of these factors. The oral activity of Indeglitazar is assessed in the ob/ob model of diabetes and insulin resistance. Indeglitazar significantly decreases glucose, insulin, triglycerides, and free fatty acid levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PPARα PPARδ PPARγ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Indolyl carboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Indolyl carboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Indolyl carboxylic acids and derivatives
Alternative Parents	3-alkylindoles Benzenesulfonamides Benzenesulfonyl compounds Phenoxy compounds Anisoles Methoxybenzenes Alkyl aryl ethers Substituted pyrroles Sulfonyls Organosulfonic acids and derivatives Heteroaromatic compounds Monocarboxylic acids and derivatives Azacyclic compounds Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Indolyl carboxylic acid derivative - 3-alkylindole - Benzenesulfonamide - Benzenesulfonyl group - Indole - Methoxybenzene - Phenol ether - Anisole - Phenoxy compound - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Substituted pyrrole - Pyrrole - Heteroaromatic compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Ether - Azacycle - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organopnictogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. These are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	3-[5-methoxy-1-(4-methoxyphenyl)sulfonylindol-3-yl]propanoic acid
INCHI	InChI=1S/C19H19NO6S/c1-25-14-4-7-16(8-5-14)27(23,24)20-12-13(3-10-19(21)22)17-11-15(26-2)6-9-18(17)20/h4-9,11-12H,3,10H2,1-2H3,(H,21,22)
InChIKey	YMPALHOKRBVHOJ-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=C2C=CC(=C3)OC)CCC(=O)O
Isomeric SMILES	COC1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=C2C=CC(=C3)OC)CCC(=O)O
PubChem CID	11395145
Molecular Weight	389.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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12 results found

Lot Number	Certificate Type	Date	Item
F2503383	Certificate of Analysis	Nov 02, 2024	I649701
F2503386	Certificate of Analysis	Nov 02, 2024	I649701
F2503388	Certificate of Analysis	Nov 02, 2024	I649701
F2503392	Certificate of Analysis	Nov 02, 2024	I649701
F2503391	Certificate of Analysis	Nov 02, 2024	I649701
F2503394	Certificate of Analysis	Nov 02, 2024	I649701
F2503384	Certificate of Analysis	Nov 02, 2024	I649701
F2503385	Certificate of Analysis	Nov 02, 2024	I649701
F2503387	Certificate of Analysis	Nov 02, 2024	I649701
F2503389	Certificate of Analysis	Nov 02, 2024	I649701
F2503390	Certificate of Analysis	Nov 02, 2024	I649701
F2503393	Certificate of Analysis	Nov 02, 2024	I649701

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Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (256.79 mM; Need ultrasonic)
Molecular Weight	389.400 g/mol
XLogP3	2.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	389.093 Da
Monoisotopic Mass	389.093 Da
Topological Polar Surface Area	103.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	610.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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