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Inauhzin - 96%, high purity , CAS No.309271-94-1

COA

Grade & Purity:

≥96%

Cas Number: 309271-94-1
Molecular Weight: 469.58
PubChem CID: 5494506
PubChem SID: 504763896

In stock

Item Number

I413611

Grouped product items
SKU	Size	Availability	Price
I413611-5mg	5mg	2	$117.90
I413611-25mg	25mg	2	$531.90
I413611-50mg	50mg	1	$533.90
I413611-100mg	100mg	2	$771.90

SIRT1 Selective Inhibitors | Activators | Modulators

View related series

Apoptosis (4276) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) Histone Modification (1379) Intrinsic Pathway (690) MDM-2/p53 (109) Sirtuin (94)

Basic Description

Synonyms	AS-16441 \| HY-N7436 \| inauhzin \| s6744 \| 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) \| AC-35922 \| METHIOCARB SULPHONE \| UNII-KX47O2O15C \| VHUOXERIKQWIJE-UHFFFAOYSA-N \| INZ \| Oprea1_520286 \| 2-((5H-[1,2,4]triazin
Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Inauhzin is a cell-permeableSIRT1inhibitor with an IC50 of 0.7-2 μM and reactivatesp53by inhibiting SIRT1 deacetylation activity. Targets SIRT1 ; p53 In vitro Inauhzin (INZ) is a potent p53 activator and mediates p53-dependent cytotoxicity. INZ inhibits cell proliferation by triggering both apoptosis and senescence in p53-containning cells, though it predominantly induces p53-dependent apoptosis. INZ is able to prevent p53 from MDM2-mediated ubiquitylation and proteasomal degradation and protects p53 without either directly inhibiting MDM2 activity towards p53 or interfering with MDMX/MDM2–p53 interaction. INZ induces acetylation of p53, but not tubulin, in cells. Inauhzin is a (sub)micromolar SIRT1i selective over SIRT2/3. In vivo Inauhzin (INZ) has good tumour tissue penetration and is able to inhibit tumour growth by inducing p53. Cell Research(from reference) Cell lines：human lung cancer H460, A549, H1299, colon cancer HCT116, HT29, osteosarcoma U2OS and SJSA, breast cancer MCF7, ovarian cancer A2780, IGROV1 and SKOV3 and glioma U87 and U373 cells, as well as human embryonic fibroblast WI-38 and normal human Concentrations：0-10 μM Incubation Time：18 h

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzothiazines
    - Subclass Phenothiazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzothiazines
Subclass	Phenothiazines
Intermediate Tree Nodes	Not available
Direct Parent	Phenothiazines
Alternative Parents	Diarylthioethers Indoles Alkylarylthioethers Benzenoids 1,4-thiazines 1,2,4-triazines Tertiary carboxylic acid amides Pyrroles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenothiazine - Diarylthioether - Indole - Indole or derivatives - Aryl thioether - Alkylarylthioether - Para-thiazine - Triazine - Benzenoid - 1,2,4-triazine - Heteroaromatic compound - Pyrrole - Tertiary carboxylic acid amide - Carboxamide group - Azacycle - Sulfenyl compound - Carboxylic acid derivative - Thioether - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organosulfur compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SIRT1 Tchem NAD-dependent protein deacetylase sirtuin-1 (1 Activities)

Discover Target: SIRT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504763896
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504763896
IUPAC Name	1-phenothiazin-10-yl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)butan-1-one
INCHI	InChI=1S/C25H19N5OS2/c1-2-19(33-25-27-23-22(28-29-25)15-9-3-4-10-16(15)26-23)24(31)30-17-11-5-7-13-20(17)32-21-14-8-6-12-18(21)30/h3-14,19H,2H2,1H3,(H,26,27,29)
InChIKey	VHUOXERIKQWIJE-UHFFFAOYSA-N
Smiles	CCC(C(=O)N1C2=CC=CC=C2SC3=CC=CC=C31)SC4=NC5=C(C6=CC=CC=C6N5)N=N4
Isomeric SMILES	CCC(C(=O)N1C2=CC=CC=C2SC3=CC=CC=C31)SC4=NC5=C(C6=CC=CC=C6N5)N=N4
WGK Germany	3
Molecular Weight	469.58
Reaxy-Rn	28301495
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28301495&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
H2220267	Certificate of Analysis	Jun 09, 2025	I413611
H2220268	Certificate of Analysis	Jun 09, 2025	I413611
H2220269	Certificate of Analysis	Jun 09, 2025	I413611
H2220266	Certificate of Analysis	Jun 09, 2025	I413611

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 94 mg/mL (200.17 mM); Water: Insoluble; Ethanol: Insoluble;
Molecular Weight	469.600 g/mol
XLogP3	5.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	469.103 Da
Monoisotopic Mass	469.103 Da
Topological Polar Surface Area	125.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	690.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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