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Stem Cell/Wnt
GSK-3
IM-12 - 95%, high purity , CAS No.1129669-05-1, Inhibitor of glycogen synthase kinase 3 beta

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IM-12 - 95%, high purity , CAS No.1129669-05-1, Inhibitor of glycogen synthase kinase 3 beta

COA

Grade & Purity:

Moligand™

≥95%

Cas Number: 1129669-05-1
Molecular Weight: 377.41
PubChem CID: 25209788
PubChem SID: 504770017

In stock

Item Number

I340238

Grouped product items
SKU	Size	Availability	Price
I340238-5mg	5mg	5	$59.90
I340238-25mg	25mg	5	$270.90
I340238-50mg	50mg	4	$357.90
I340238-100mg	100mg	4	$602.90

View related series

glycogen synthase kinase 3 beta Inhibitor (44) GSK-3 (104) PI3K/Akt/mTOR (765) Stem Cell/Wnt (1019)

Basic Description

Synonyms	A14196 \| BRD-K69241845-001-01-0 \| 3-Methoxy-17alpha-ethinylestradiol \| GTPL8017 \| C22H20FN3O2 \| s7566 \| IM12 \| IM-12 \| 1129669-05-1 \| BCP10769 \| DTXSID20649091 \| SCHEMBL17378682 \| FT-0730225 \| HY-12292 \| Q27078043 \| AC-32946 \| IM 12 \| SW219497-1 \| AS-5582
Specifications & Purity	Moligand™, ≥95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of glycogen synthase kinase 3 beta

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives
Direct Parent	Alpha amino acids and derivatives
Alternative Parents	Phenethylamines Indoles Aralkylamines Fluorobenzenes Maleimides Substituted pyrroles Aryl fluorides N-substituted carboxylic acid imides Vinylogous amides Pyrrolines Dicarboximides Heteroaromatic compounds Enamines Azacyclic compounds Dialkylamines Organopnictogen compounds Carbonyl compounds Hydrocarbon derivatives Organofluorides Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Alpha-amino acid or derivatives - Indole - Indole or derivatives - Phenethylamine - Fluorobenzene - Halobenzene - Aralkylamine - Maleimide - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Carboxylic acid imide, n-substituted - Benzenoid - Substituted pyrrole - Carboxylic acid imide - Dicarboximide - Heteroaromatic compound - Vinylogous amide - Pyrrole - Pyrroline - Secondary amine - Secondary aliphatic amine - Organoheterocyclic compound - Azacycle - Enamine - Organic oxide - Hydrocarbon derivative - Amine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organofluoride - Organonitrogen compound - Organooxygen compound - Organohalogen compound - Organopnictogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GSK3B Tclin Glycogen synthase kinase-3 beta (1 Activities)

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770017
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770017
IUPAC Name	3-[2-(4-fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione
INCHI	InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
InChIKey	ZKJAZFUFPPSFCO-UHFFFAOYSA-N
Smiles	CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F
Molecular Weight	377.41
Reaxy-Rn	19097379
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19097379&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
G2322557	Certificate of Analysis	Jun 26, 2023	I340238
G2322554	Certificate of Analysis	Jun 26, 2023	I340238
G2322560	Certificate of Analysis	Jun 26, 2023	I340238
G2322567	Certificate of Analysis	Jun 26, 2023	I340238
G2322558	Certificate of Analysis	Jun 26, 2023	I340238
G2322575	Certificate of Analysis	Jun 26, 2023	I340238
G2322566	Certificate of Analysis	Jun 26, 2023	I340238
G2322571	Certificate of Analysis	Jun 26, 2023	I340238

Chemical and Physical Properties

Sensitivity	Moisture sensitive
Molecular Weight	377.400 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	377.154 Da
Monoisotopic Mass	377.154 Da
Topological Polar Surface Area	65.200 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	656.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Alternative Products

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