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ILK-IN-3 - 99%, high purity , CAS No.6975-75-3

COA

Grade & Purity:

≥99%

Cas Number: 6975-75-3
Molecular Weight: 232.24
PubChem CID: 228619

In stock

Item Number

I649033

Grouped product items
SKU	Size	Availability	Price
I649033-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$220.90
I649033-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
I649033-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$630.90
I649033-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90

View related series

Cytoskeleton (498) DYRK (39) Integrin (90) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314)

Basic Description

Synonyms	DTXSID00903507 \| SMR000283426 \| BRD-K81404764-001-08-0 \| QLT-0267; QLT 0267; QLT0267; QLT-267; QLT 267; QLT267 \| SY001832 \| MLS000737992 \| NIOSH/UV9738000 \| STK020105 \| SCHEMBL924770 \| (4E)-5-IMINO-4-[2-(4-METHOXYPHENYL)HYDRAZIN-1-YLIDENE]-4,5-DIHYDRO-1H-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	ILK-IN-3 is an orally active integrin linked kinase (ILK) inhibitor. ILK-IN-3 improves the anticancer efficacy of Docetaxel ( HY-B0011 ) in orthotopic LCC6 model.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	ILK-IN-3 is an orally active integrin linked kinase (ILK) inhibitor. ILK-IN-3 improves the anticancer efficacy of Docetaxel in orthotopic LCC6 model. In Vitro ILK-IN-3 (compound 4, 10 μM) inhibits DYRK1, GSK3α/β, CDK5/p25 kinase activity to 17%, 51%, 47%, 95%, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ILK-IN-3 (QLT0267) (200 mg/kg，口服，28 天) 抑制原位 LCC6 模型中的肿瘤生长。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Aniline and substituted anilines

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Aniline and substituted anilines
Intermediate Tree Nodes	Not available
Direct Parent	Methoxyanilines
Alternative Parents	Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Imidolactams Pyrazoles Heteroaromatic compounds Azo compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Primary amines Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Methoxyaniline - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Imidolactam - Heteroaromatic compound - Azole - Pyrazole - Azo compound - Azacycle - Ether - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organonitrogen compound - Amine - Organic nitrogen compound - Organooxygen compound - Organic oxygen compound - Primary amine - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as methoxyanilines. These are organic compound containing an aniline group substituted at one or more positions by a methoxy group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	4-[(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
INCHI	InChI=1S/C10H12N6O/c1-17-7-4-2-6(3-5-7)13-14-8-9(11)15-16-10(8)12/h2-5H,1H3,(H5,11,12,15,16)
InChIKey	QNRNTYHAOBVOKW-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)N=NC2=C(NN=C2N)N
Isomeric SMILES	COC1=CC=C(C=C1)N=NC2=C(NN=C2N)N
PubChem CID	228619
Molecular Weight	232.24

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 83.33 mg/mL (358.81 mM; Need ultrasonic)
Molecular Weight	232.240 g/mol
XLogP3	1.300
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	232.107 Da
Monoisotopic Mass	232.107 Da
Topological Polar Surface Area	115.000 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	266.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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