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ICCB-19 hydrochloride - 99%, high purity , CAS No.1803605-68-6

COA

Grade & Purity:

≥99%

Cas Number: 1803605-68-6
Molecular Weight: 291.84
PubChem CID: 91654402
PubChem SID: 504772630

In stock

Item Number

I413405

Grouped product items
SKU	Size	Availability	Price
I413405-5mg	5mg	1	$58.90
I413405-10mg	10mg	1	$98.90
I413405-25mg	25mg	1	$197.90
I413405-50mg	50mg	1	$296.90
I413405-100mg	100mg	2	$444.90

RIP kinase Inhibitors

View related series

Apoptosis (4276) Autophagy (1917) Extrinsic Pathway (436) RIP kinase (65)

Basic Description

Synonyms	EN300-195751 \| s6078 \| ICCB-19 HCl pound 750621-52-4 free base pound(c) \| N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride \| E74676 \| MS-24169 \| EX-A6564 \| HY-138779 \| ICCB-19 hydrochloride \| N-cycloheptyl-2-(4,5-dihydro-1H-im
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) . ICCB-19 effectively induces autophagy . Targets TRADD ; RIPK1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azolines
    - Subclass Imidazolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azolines
Subclass	Imidazolines
Intermediate Tree Nodes	Not available
Direct Parent	Imidazolines
Alternative Parents	Secondary carboxylic acid amides Isothioureas Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Carboximidamides Azacyclic compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	2-imidazoline - Carboxamide group - Isothiourea - Secondary carboxylic acid amide - Carboxylic acid derivative - Carboximidamide - Sulfenyl compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Organic oxygen compound - Hydrochloride - Organic oxide - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as imidazolines. These are organic compounds containing an imidazoline ring, which is an unsaturated ring (derived from imidazole) with two nitrogen atoms at positions 1 and 3 respectively, and containing only one CN double bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504772630
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772630
IUPAC Name	N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide;hydrochloride
INCHI	InChI=1S/C12H21N3OS.ClH/c16-11(9-17-12-13-7-8-14-12)15-10-5-3-1-2-4-6-10;/h10H,1-9H2,(H,13,14)(H,15,16);1H
InChIKey	TZICOTBZKPHMMK-UHFFFAOYSA-N
Smiles	C1CCCC(CC1)NC(=O)CSC2=NCCN2.Cl
Isomeric SMILES	C1CCCC(CC1)NC(=O)CSC2=NCCN2.Cl
PubChem CID	91654402
Molecular Weight	291.84

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
G2219676	Certificate of Analysis	May 09, 2025	I413405
G2219677	Certificate of Analysis	May 09, 2025	I413405
G2219738	Certificate of Analysis	May 09, 2025	I413405
G2219637	Certificate of Analysis	May 09, 2025	I413405
G2219739	Certificate of Analysis	May 09, 2025	I413405

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 58 mg/mL (198.73 mM); Water: 58 mg/mL (198.73 mM); Ethanol: 58 mg/mL (198.73 mM);
Sensitivity	light sensitive
Molecular Weight	291.840 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	291.117 Da
Monoisotopic Mass	291.117 Da
Topological Polar Surface Area	78.800 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	285.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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