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Hypocrellin A - 98%, high purity , CAS No.77029-83-5

COA

Grade & Purity:

≥98%

Cas Number: 77029-83-5
Molecular Weight: 546.52
PubChem CID: 3664
PubChem SID: 504750694

In stock

Item Number

H275027

Grouped product items
SKU	Size	Availability	Price
H275027-1mg	1mg	3	$118.90
H275027-5mg	5mg	3	$237.90
H275027-10mg	10mg	3	$375.90
H275027-25mg	25mg	3	$674.90
H275027-50mg	50mg	3	$1,214.90

Potent PKC inhibitor. Photosensitizing agent.

View related series

Anti-infection (2803) Apoptosis (4276) Bacterial (3013) Epigenetics (1496) Histone Modification (1379) Intrinsic Pathway (690) Parasite (997) PKC (132) Receptor Tyrosine Kinase (1260) TGF-beta/Smad (303) Virus (1811)

Basic Description

Synonyms	AKOS040758769 \| FT-0777753 \| acetyl-trihydroxy-tetramethoxy-methyl-[?]dione \| 1-Acetyl-2,6,11-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-5,12-dione \| (12R,13S)-12-acetyl-9,13,17-trihydroxy-5,10,16,21-tetramethoxy-13-m
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent PKC inhibitor. Photosensitizing agent. Potent antileishmanial agent. Selective class II-MHC restricted presentation of exogenous antigen inhibitor. Shows antitumor, antifungal and antiviral effects in vivo.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A is a promising photosensitizer for anticancer photodynamic therapy (PDT).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Perylenequinones

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Perylenequinones
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Perylenequinones
Alternative Parents	Phenanthrols Anthracenes Naphthols and derivatives Anisoles Alkyl aryl ethers Vinylogous esters Vinylogous acids Tertiary alcohols Ketones Polyols Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Perylenequinone - Phenanthrol - Anthracene - Phenanthrene - 1-naphthol - 2-naphthol - Anisole - Alkyl aryl ether - Vinylogous ester - Vinylogous acid - Tertiary alcohol - Ketone - Polyol - Ether - Alcohol - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as perylenequinones. These are heterocyclic compounds characterized by two 8-hydroxy-1,4-dihydronaphthalen-1-one moieties joined together one or two CC-bonds.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504750694
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504750694
IUPAC Name	12-acetyl-9,13,17-trihydroxy-5,10,16,21-tetramethoxy-13-methylhexacyclo[13.8.0.02,11.03,8.04,22.018,23]tricosa-1(15),2(11),3(8),4(22),5,9,16,18(23),20-nonaene-7,19-dione
INCHI	InChI=1S/C30H26O10/c1-10(31)25-24-22-16-11(9-30(25,2)36)28(39-5)26(34)17-12(32)7-14(37-3)19(21(16)17)20-15(38-4)8-13(33)18(23(20)22)27(35)29(24)40-6/h7-8,25,34-36H,9H2,1-6H3
InChIKey	VANSZAOQCMTTPB-UHFFFAOYSA-N
Smiles	CC(=O)C1C2=C3C4=C(CC1(C)O)C(=C(C5=C4C(=C6C3=C(C(=O)C=C6OC)C(=C2OC)O)C(=CC5=O)OC)O)OC
Isomeric SMILES	CC(=O)C1C2=C3C4=C(CC1(C)O)C(=C(C5=C4C(=C6C3=C(C(=O)C=C6OC)C(=C2OC)O)C(=CC5=O)OC)O)OC
Molecular Weight	546.52
Reaxy-Rn	7897946
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7897946&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2528149	Certificate of Analysis	Apr 15, 2025	H275027
B23031420	Certificate of Analysis	Nov 10, 2023	H275027
B23031450	Certificate of Analysis	Nov 10, 2023	H275027
B23031451	Certificate of Analysis	Nov 10, 2023	H275027
B23031419	Certificate of Analysis	Nov 10, 2023	H275027
B23031452	Certificate of Analysis	Nov 10, 2023	H275027

Chemical and Physical Properties

Solubility	Soluble in DMSO
Sensitivity	Light sensitive
Molecular Weight	546.500 g/mol
XLogP3	4.000
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Exact Mass	546.153 Da
Monoisotopic Mass	546.153 Da
Topological Polar Surface Area	149.000 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	1180.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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