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Hydroxytyrosol - 10mM in DMSO, high purity , CAS No.10597-60-1

    Grade & Purity:
  • 10mM in DMSO
  • Cas Number:  10597-60-1
  • Molecular Weight:  154.16
  • Beilstein Registry Number:   2208118
  • PubChem CID: 82755
In stock
Item Number
H420486
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H420486-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$152.90

Antioxidant agent. 5- and 12-lipoxygenase inhibitor.

Basic Description

Synonyms Hydroxytyrosol | 10597-60-1 | 3,4-Dihydroxyphenylethanol | 4-(2-hydroxyethyl)benzene-1,2-diol | 2-(3,4-Dihydroxyphenyl)ethanol | 3,4-Dihydroxyphenethyl Alcohol | dopet | 3-Hydroxytyrosol | 1,2-Benzenediol, 4-(2-hydroxyethyl)- | 3,4-Dihydroxyphenethylalcohol | 2-(3,4-Dihydrox
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms Antioxidant agent. 5- and 12-lipoxygenase inhibitor (IC 50 values are 13 and 4.2 μM, respectively). Shows anti-inflammatory and antioxidant effects in vivo. Orally active.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Phenols
Subclass Tyrosols and derivatives
Intermediate Tree Nodes Not available
Direct Parent Tyrosols
Alternative Parents Catechols  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Benzene and substituted derivatives  Primary alcohols  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Tyrosol - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as tyrosols. These are organic aromatic compounds containing a phenethyl alcohol moiety that carries a hydroxyl group at the 4-position of the benzene group.
External Descriptors catechols - primary alcohol

Associated Targets(Human)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
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PANC-1 (6144 Activities)
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PC-3 (62116 Activities)
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SH-SY5Y (11521 Activities)
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SK-BR-3 (5175 Activities)
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SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DG-75 (165 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aspergillus niger (16508 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella enterica (1497 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDCK (10148 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-(2-hydroxyethyl)benzene-1,2-diol
INCHI InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
InChIKey JUUBCHWRXWPFFH-UHFFFAOYSA-N
Smiles C1=CC(=C(C=C1CCO)O)O
Isomeric SMILES C1=CC(=C(C=C1CCO)O)O
WGK Germany 3
Molecular Weight 154.16
Beilstein 2208118
Reaxy-Rn 2208118
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2208118&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity air sensitive
Refractive Index 1.58
Molecular Weight 154.160 g/mol
XLogP3 -0.700
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 2
Exact Mass 154.063 Da
Monoisotopic Mass 154.063 Da
Topological Polar Surface Area 60.700 Ų
Heavy Atom Count 11
Formal Charge 0
Complexity 116.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Shuyan Han, Hongmei Hou, Yiren Zhang, Zhongxiang Fang, Yun Li, Le Zhang, Yandan Wang, Shijia Zhang, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang.  (2023)  Oleuropein and its hydrolysate from extra virgin olive oil inhibit breast cancer cells proliferation interfering with the PI3K-AKT signal pathway.  Journal of Functional Foods,  110  (105880). 
2. Chenchen Zhao, Yu Sha, Wei Zhuang, Yuan Rao, Jihang Zhang, Jinglan Wu, Tao Shen, Zhuotao Tan, Chenjie Zhu, Hongman Zhang, Hanjie Ying.  (2023)  Production of hydroxytyrosol from tyrosol via controllable oxidation with immobilized tyrosinase: A comparative study.  PROCESS BIOCHEMISTRY,  131  (144). 
3. Fengxia Tang, Chuan Li, Xiaoran Yang, Jiandu Lei, Hongxia Chen, Changwei Zhang, Chengzhang Wang.  (2023)  Effect of Variety and Maturity Index on the Physicochemical Parameters Related to Virgin Olive Oil from Wudu (China).  Foods,  12  (1): (7). 
4. Fan Wu, Fulin Tian, Zhou Jin, Jing Liu, Weiping Jin, Xuan Chen, Zhan Wang, Xiwu Jia, Benguo Liu, Lingyi Liu, Wangyang Shen.  (2022)  Antioxidant capacities of heat-treated wheat germ and extruded compounded bran.  CEREAL CHEMISTRY,  99  (3): (582-592). 
5. Xiaorong Zhang, Yun Jiang, Jiajie Mao, Xuekun Ren, Yinghui Ji, Yixin Mao, Yang Chen, Xiaoyu Sun, Yihuai Pan, Jianfeng Ma, Shengbin Huang.  (2021)  Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells.  FREE RADICAL BIOLOGY AND MEDICINE,  176  (298). 
6. Mingtao Zhao, Xulin Hong, Abdullah, Ruilian Yao, Yi Xiao.  (2021)  Rapid biosynthesis of phenolic glycosides and their derivatives from biomass-derived hydroxycinnamates.  GREEN CHEMISTRY,  23  (2): (838-847). 
7. Yang Li, Ying Peng, Ping Ma, Mengyue Wang, Chongsheng Peng, Pengfei Tu, Xiaobo Li.  (2019)  In vitro and in vivo metabolism of Cistanche tubulosa extract in normal and chronic unpredictable stress-induced depressive rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1125  (121728). 
8. Jiahong Han, Min Dai, Yan Zhao, Enbo Cai, Lianxue Zhang, Xiaohuan Jia, Nian Sun, Xuan Fei, Hui Shu.  (2020)  Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis.  Journal of Ginseng Research,  44  (291). 
9. Hao QIAN, Fang-Jun YU, Dan-Yi LU, Bao-Jian WU, Xing-Wang ZHANG, Huan WANG, Zhi-Guo MA.  (2018)  Identification of poliumoside metabolites in rat plasma, urine, bile, and intestinal bacteria with UPLC/Q-TOF-MS.  Chinese Journal of Natural Medicines,  16  (871). 
10. Li-xing Wu, Yu-yu Xu, Zhi-jian Yang, Qing Feng.  (2018)  Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression.  Journal of Biomedical Research,  32  (5): ( 371–379). 
11. Lingyi Liu, Zhou Jin, Min Wang, Wangyang Shen, Zhenzhou Zhu, Zhan Wang, Lianliang Liu.  (2018)  W/O Nano-Emulsions with Olive Leaf Phenolics Improved Oxidative Stability of Sacha Inchi Oil.  EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY,  120  (5): (1700471). 
12. Zhihong Wang, Chengzhang Wang, Changwei Zhang, Wenjun Li.  (2017)  Ultrasound-assisted enzyme catalyzed hydrolysis of olive waste and recovery of antioxidant phenolic compounds.  Innovative Food Science & Emerging Technologies,  44  (224). 
13. Yang Li, Guisheng Zhou, Ying Peng, Pengfei Tu, Xiaobo Li.  (2016)  Screening and identification of three typical phenylethanoid glycosides metabolites from Cistanches Herba by human intestinal bacteria using UPLC/Q-TOF-MS.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  118  (167). 
14. Yang Li,Ying Peng,Mengyue Wang,Guisheng Zhou,Yulong Zhang,Xiaobo Li.  (2016-09-19)  Rapid screening and identification of the differences between metabolites of Cistanche deserticola and C. tubulosa water extract in rats by UPLC-Q-TOF-MS combined pattern recognition analysis..  Journal of pharmaceutical and biomedical analysis,  131  (364-372). 
15. Yang Li,Ying Peng,Mengyue Wang,Pengfei Tu,Xiaobo Li.  (2017-08-05)  Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes..  Journal of agricultural and food chemistry,  65  ((34)): (7447-7456). 
16. Shiming Tang, Zhilin Ouyang, Ying Huo, Daocheng Liao, Zhiteng Zhang, Ying Lin, Suiping Zheng.  (2024)  An engineered dual-functional L-DOPA decarboxylase enables a minimized hydroxytyrosol cascade.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (138176). 
17. Meiyu Gu, Jiahui Shi, Boya Zhang, Xibo Wang, Xu Wang.  (2024)  Covalent modification of soy protein isolates by hydroxytyrosol: Effects on structural and functional properties of adducts.  LWT-FOOD SCIENCE AND TECHNOLOGY,  198  (116041). 
18. Tian Xia, Xiao-jiang Mao, Jian Zhang, Samad Rahimnejad, Kang-le Lu.  (2024)  Effects of quercetin and hydroxytyrosol supplementation in a high-fat diet on growth, lipid metabolism, and mitochondrial function in spotted seabass (Lateolabrax maculatus).  AQUACULTURE,  582  (740538). 
19. Wen-Kai Liu, Xiu-Xin Ren, Lian Xu, Juan Lin.  (2025)  Modular cascade with engineered HpaB for efficient synthesis of hydroxytyrosol.  BIOORGANIC CHEMISTRY,    (108125). 
20. Wen-Kai Liu, Bing-Mei Su, Xin-Qi Xu, Lian Xu, Juan Lin.  (2024)  Multienzymatic Cascade for Synthesis of Hydroxytyrosol via Two-Stage Biocatalysis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  72  (27): (15293-15300). 
21. Yi Wang, Ruge Lin, Laiming Zhang, Suqing Lan, Xingqian Ye, Haibo Pan, Shiguo Chen.  (2025)  Oxygen influences in vitro assessment for phenolic compounds: Digestive stability, α-glucosidase inhibitory activity and bioavailability.  FOOD CHEMISTRY,  466  (142165). 

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