Determine the necessary mass, volume, or concentration for preparing a solution.
This is a demo store. No orders will be fulfilled.
| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
H420486-1ml
|
1ml |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$152.90
|
|
Antioxidant agent. 5- and 12-lipoxygenase inhibitor.
| Synonyms | Hydroxytyrosol | 10597-60-1 | 3,4-Dihydroxyphenylethanol | 4-(2-hydroxyethyl)benzene-1,2-diol | 2-(3,4-Dihydroxyphenyl)ethanol | 3,4-Dihydroxyphenethyl Alcohol | dopet | 3-Hydroxytyrosol | 1,2-Benzenediol, 4-(2-hydroxyethyl)- | 3,4-Dihydroxyphenethylalcohol | 2-(3,4-Dihydrox |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Antioxidant agent. 5- and 12-lipoxygenase inhibitor (IC 50 values are 13 and 4.2 μM, respectively). Shows anti-inflammatory and antioxidant effects in vivo. Orally active. |
| Storage Temp | Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Phenols |
| Subclass | Tyrosols and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Tyrosols |
| Alternative Parents | Catechols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Primary alcohols Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Tyrosol - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as tyrosols. These are organic aromatic compounds containing a phenethyl alcohol moiety that carries a hydroxyl group at the 4-position of the benzene group. |
| External Descriptors | catechols - primary alcohol |
|
|
|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 4-(2-hydroxyethyl)benzene-1,2-diol |
|---|---|
| INCHI | InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2 |
| InChIKey | JUUBCHWRXWPFFH-UHFFFAOYSA-N |
| Smiles | C1=CC(=C(C=C1CCO)O)O |
| Isomeric SMILES | C1=CC(=C(C=C1CCO)O)O |
| WGK Germany | 3 |
| Molecular Weight | 154.16 |
| Beilstein | 2208118 |
| Reaxy-Rn | 2208118 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2208118&ln= |
| Sensitivity | air sensitive |
|---|---|
| Refractive Index | 1.58 |
| Molecular Weight | 154.160 g/mol |
| XLogP3 | -0.700 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 2 |
| Exact Mass | 154.063 Da |
| Monoisotopic Mass | 154.063 Da |
| Topological Polar Surface Area | 60.700 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 116.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Shuyan Han, Hongmei Hou, Yiren Zhang, Zhongxiang Fang, Yun Li, Le Zhang, Yandan Wang, Shijia Zhang, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang. (2023) Oleuropein and its hydrolysate from extra virgin olive oil inhibit breast cancer cells proliferation interfering with the PI3K-AKT signal pathway. Journal of Functional Foods, 110 (105880). |
| 2. Chenchen Zhao, Yu Sha, Wei Zhuang, Yuan Rao, Jihang Zhang, Jinglan Wu, Tao Shen, Zhuotao Tan, Chenjie Zhu, Hongman Zhang, Hanjie Ying. (2023) Production of hydroxytyrosol from tyrosol via controllable oxidation with immobilized tyrosinase: A comparative study. PROCESS BIOCHEMISTRY, 131 (144). |
| 3. Fengxia Tang, Chuan Li, Xiaoran Yang, Jiandu Lei, Hongxia Chen, Changwei Zhang, Chengzhang Wang. (2023) Effect of Variety and Maturity Index on the Physicochemical Parameters Related to Virgin Olive Oil from Wudu (China). Foods, 12 (1): (7). |
| 4. Fan Wu, Fulin Tian, Zhou Jin, Jing Liu, Weiping Jin, Xuan Chen, Zhan Wang, Xiwu Jia, Benguo Liu, Lingyi Liu, Wangyang Shen. (2022) Antioxidant capacities of heat-treated wheat germ and extruded compounded bran. CEREAL CHEMISTRY, 99 (3): (582-592). |
| 5. Xiaorong Zhang, Yun Jiang, Jiajie Mao, Xuekun Ren, Yinghui Ji, Yixin Mao, Yang Chen, Xiaoyu Sun, Yihuai Pan, Jianfeng Ma, Shengbin Huang. (2021) Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells. FREE RADICAL BIOLOGY AND MEDICINE, 176 (298). |
| 6. Mingtao Zhao, Xulin Hong, Abdullah, Ruilian Yao, Yi Xiao. (2021) Rapid biosynthesis of phenolic glycosides and their derivatives from biomass-derived hydroxycinnamates. GREEN CHEMISTRY, 23 (2): (838-847). |
| 7. Yang Li, Ying Peng, Ping Ma, Mengyue Wang, Chongsheng Peng, Pengfei Tu, Xiaobo Li. (2019) In vitro and in vivo metabolism of Cistanche tubulosa extract in normal and chronic unpredictable stress-induced depressive rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1125 (121728). |
| 8. Jiahong Han, Min Dai, Yan Zhao, Enbo Cai, Lianxue Zhang, Xiaohuan Jia, Nian Sun, Xuan Fei, Hui Shu. (2020) Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis. Journal of Ginseng Research, 44 (291). |
| 9. Hao QIAN, Fang-Jun YU, Dan-Yi LU, Bao-Jian WU, Xing-Wang ZHANG, Huan WANG, Zhi-Guo MA. (2018) Identification of poliumoside metabolites in rat plasma, urine, bile, and intestinal bacteria with UPLC/Q-TOF-MS. Chinese Journal of Natural Medicines, 16 (871). |
| 10. Li-xing Wu, Yu-yu Xu, Zhi-jian Yang, Qing Feng. (2018) Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression. Journal of Biomedical Research, 32 (5): ( 371–379). |
| 11. Lingyi Liu, Zhou Jin, Min Wang, Wangyang Shen, Zhenzhou Zhu, Zhan Wang, Lianliang Liu. (2018) W/O Nano-Emulsions with Olive Leaf Phenolics Improved Oxidative Stability of Sacha Inchi Oil. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 120 (5): (1700471). |
| 12. Zhihong Wang, Chengzhang Wang, Changwei Zhang, Wenjun Li. (2017) Ultrasound-assisted enzyme catalyzed hydrolysis of olive waste and recovery of antioxidant phenolic compounds. Innovative Food Science & Emerging Technologies, 44 (224). |
| 13. Yang Li, Guisheng Zhou, Ying Peng, Pengfei Tu, Xiaobo Li. (2016) Screening and identification of three typical phenylethanoid glycosides metabolites from Cistanches Herba by human intestinal bacteria using UPLC/Q-TOF-MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 118 (167). |
| 14. Yang Li,Ying Peng,Mengyue Wang,Guisheng Zhou,Yulong Zhang,Xiaobo Li. (2016-09-19) Rapid screening and identification of the differences between metabolites of Cistanche deserticola and C. tubulosa water extract in rats by UPLC-Q-TOF-MS combined pattern recognition analysis.. Journal of pharmaceutical and biomedical analysis, 131 (364-372). |
| 15. Yang Li,Ying Peng,Mengyue Wang,Pengfei Tu,Xiaobo Li. (2017-08-05) Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes.. Journal of agricultural and food chemistry, 65 ((34)): (7447-7456). |
| 16. Shiming Tang, Zhilin Ouyang, Ying Huo, Daocheng Liao, Zhiteng Zhang, Ying Lin, Suiping Zheng. (2024) An engineered dual-functional L-DOPA decarboxylase enables a minimized hydroxytyrosol cascade. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (138176). |
| 17. Meiyu Gu, Jiahui Shi, Boya Zhang, Xibo Wang, Xu Wang. (2024) Covalent modification of soy protein isolates by hydroxytyrosol: Effects on structural and functional properties of adducts. LWT-FOOD SCIENCE AND TECHNOLOGY, 198 (116041). |
| 18. Tian Xia, Xiao-jiang Mao, Jian Zhang, Samad Rahimnejad, Kang-le Lu. (2024) Effects of quercetin and hydroxytyrosol supplementation in a high-fat diet on growth, lipid metabolism, and mitochondrial function in spotted seabass (Lateolabrax maculatus). AQUACULTURE, 582 (740538). |
| 19. Wen-Kai Liu, Xiu-Xin Ren, Lian Xu, Juan Lin. (2025) Modular cascade with engineered HpaB for efficient synthesis of hydroxytyrosol. BIOORGANIC CHEMISTRY, (108125). |
| 20. Wen-Kai Liu, Bing-Mei Su, Xin-Qi Xu, Lian Xu, Juan Lin. (2024) Multienzymatic Cascade for Synthesis of Hydroxytyrosol via Two-Stage Biocatalysis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72 (27): (15293-15300). |
| 21. Yi Wang, Ruge Lin, Laiming Zhang, Suqing Lan, Xingqian Ye, Haibo Pan, Shiguo Chen. (2025) Oxygen influences in vitro assessment for phenolic compounds: Digestive stability, α-glucosidase inhibitory activity and bioavailability. FOOD CHEMISTRY, 466 (142165). |