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Hydroxyhomosildenafil - 95%, high purity , CAS No.139755-85-4

COA

Grade & Purity:

≥95%

Cas Number: 139755-85-4
Molecular Weight: 504.60
PubChem CID: 135452901

In stock

Item Number

H276052

Grouped product items
SKU	Size	Availability	Price
H276052-1mg	1mg	3	$30.90
H276052-5mg	5mg	3	$92.90
H276052-10mg	10mg	3	$157.90
H276052-25mg	25mg	3	$315.90
H276052-50mg	50mg	2	$536.90
H276052-100mg	100mg	2	$750.90
H276052-250mg	250mg	1	$1,314.90

Sildenafil analog. Phosphodiesterase type 5 (PDE5) inhibitor.

View related series

inhibitor (73) Metabolic Enzyme/Protease (4860) Nucleic Acid Metabolism (395) Phosphodiesterase (PDE) (252) Piperazines (158)

Basic Description

Synonyms	Chronadalate LP \| SCHEMBL18416781 \| 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-; 1-Piperazineethanol, 4-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyri
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Sildenafil analog. Phosphodiesterase type 5 (PDE5) inhibitor.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Lodenafil is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	Benzenesulfonyl compounds Pyrazolopyrimidines Phenol ethers Phenoxy compounds Alkyl aryl ethers N-alkylpiperazines Pyrimidones Organosulfonamides Vinylogous amides Heteroaromatic compounds Sulfonyls Pyrazoles 1,2-aminoalcohols Trialkylamines Azacyclic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary alcohols
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzenesulfonamide - Pyrazolopyrimidine - Benzenesulfonyl group - Phenoxy compound - Phenol ether - Alkyl aryl ether - Pyrimidone - N-alkylpiperazine - Pyrimidine - 1,4-diazinane - Piperazine - Organosulfonic acid amide - Pyrazole - Azole - Heteroaromatic compound - Sulfonyl - Vinylogous amide - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - 1,2-aminoalcohol - Tertiary amine - Tertiary aliphatic amine - Alkanolamine - Ether - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Amine - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Primary alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase (2 Activities)

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

Discover Target: PDE5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3 (1749 Activities)

Discover Target: PDE3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
INCHI	InChI=1S/C23H32N6O5S/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,31)
InChIKey	NEYKRKVLEWKOBI-UHFFFAOYSA-N
Smiles	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCO)OCC)C
Isomeric SMILES	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCO)OCC)C
Molecular Weight	504.60
Reaxy-Rn	7674756
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7674756&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number	Certificate Type	Date	Item
C2412261	Certificate of Analysis	Jun 17, 2025	H276052
C2412255	Certificate of Analysis	May 15, 2025	H276052
C2412258	Certificate of Analysis	May 15, 2025	H276052
C2412269	Certificate of Analysis	May 15, 2025	H276052
C2412271	Certificate of Analysis	May 15, 2025	H276052
C2412273	Certificate of Analysis	May 15, 2025	H276052
C2412275	Certificate of Analysis	May 15, 2025	H276052
C2412260	Certificate of Analysis	Dec 05, 2024	H276052
C2412257	Certificate of Analysis	Dec 05, 2024	H276052
C2412262	Certificate of Analysis	Dec 05, 2024	H276052
C2412270	Certificate of Analysis	Dec 05, 2024	H276052
C2412272	Certificate of Analysis	Dec 05, 2024	H276052
C2412274	Certificate of Analysis	Dec 05, 2024	H276052
C2412276	Certificate of Analysis	Dec 05, 2024	H276052
A2412276	Certificate of Analysis	Jan 25, 2024	H276052

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Chemical and Physical Properties

Molecular Weight	504.600 g/mol
XLogP3	0.800
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Exact Mass	504.215 Da
Monoisotopic Mass	504.215 Da
Topological Polar Surface Area	138.000 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	872.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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