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Hydrocortisone 21-hemisuccinate sodium salt - 10mM in DMSO, high purity , CAS No.125-04-2, Glucocorticoid receptor agonist
Basic Description
Synonyms
Hydrocortisone sodium succinate | A-hydroCort | 125-04-2 | Arcocort | Buccalsone | Corlan | Cortop | Solu-Cortef | Emi-Corlin | Hidrokortizon | Nositrol | Rapicort | Lycortin-S | Hydrocortisone 21-hemisuccinate sodium salt | Cortisol 21-(sodium succinate) | Flebocortid | Hycorace | Intrac
Specifications & Purity
10mM in DMSO
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
AGONIST
Mechanism of action
Glucocorticoid receptor agonist
Product Description
Hydrocortisone 21-hemisuccinate sodium salt is a water-soluble form of the endogenous hormone cortisol. Hydrocortisone 21-hemisuccinate sodium salt is useful for epithelial and endothelial adherent cell culture applications. Since Hydrocortisone 21-hemisuccinate sodium salt can bind to glucocorticoid receptors, the transcription of anti-inflammatory nand immunosuppressive mediators can be initiated. Hydrocortisone 21-hemisuccinate sodium salt will also inhibit proinflammatory cytokine activity.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Subclass
Pregnane steroids
Intermediate Tree Nodes
Not available
Direct Parent
Gluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
20-oxosteroids 11-beta-hydroxysteroids 17-hydroxysteroids 3-oxo delta-4-steroids Delta-4-steroids Alpha-acyloxy ketones Cyclohexenones Dicarboxylic acids and derivatives Tertiary alcohols Alpha-hydroxy ketones Secondary alcohols Cyclic alcohols and derivatives Carboxylic acid esters Carboxylic acid salts Carboxylic acids Hydrocarbon derivatives Organic zwitterions Organic sodium salts Organic oxides
Molecular Framework
Aliphatic homopolycyclic compounds
Substituents
Progestogin-skeleton - 20-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - Hydroxysteroid - 17-hydroxysteroid - 11-hydroxysteroid - 11-beta-hydroxysteroid - Oxosteroid - Delta-4-steroid - Cyclohexenone - Alpha-acyloxy ketone - Dicarboxylic acid or derivatives - Alpha-hydroxy ketone - Cyclic alcohol - Tertiary alcohol - Carboxylic acid ester - Carboxylic acid salt - Cyclic ketone - Ketone - Secondary alcohol - Organic alkali metal salt - Carboxylic acid - Carboxylic acid derivative - Organic salt - Organic sodium salt - Organic oxide - Organic oxygen compound - Carbonyl group - Organic zwitterion - Alcohol - Organooxygen compound - Hydrocarbon derivative - Aliphatic homopolycyclic compound
Description
This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
External Descriptors
organic molecular entity
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
INCHI
InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
InChIKey
HHZQLQREDATOBM-CODXZCKSSA-M
Smiles
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
WGK Germany
3
RTECS
GM9015000
Molecular Weight
484.51
Reaxy-Rn
37058057
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37058057&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
484.500 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Rotatable Bond Count
7
Exact Mass
484.207 Da
Monoisotopic Mass
484.207 Da
Topological Polar Surface Area
141.000 Ų
Heavy Atom Count
34
Formal Charge
0
Complexity
915.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
7
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
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