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HS024 TFA, Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor, CAS No.212370-59-7(free base), Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

In stock
Item Number
H288535
Grouped product items
SKU Size
Availability
Price Qty
H288535-1mg
1mg
3
$129.90
H288535-5mg
5mg
3
$299.90
H288535-10mg
10mg
2
$499.90
H288535-25mg
25mg
1
$999.90

Highly potent MC4receptor antagonist

Basic Description

Product Name HS024 TFA, Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor, CAS No.212370-59-7(free base)
Synonyms AKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)
Grade Moligand™
Specifications & Purity Moligand™, ≥95%
Biochemical and Physiological Mechanisms Highly potent melanocortin MC4receptor antagonist (Kivalues are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3and MC5receptors respectively). Increases food intake, and blocksα-MSH- and MTII-induced hypotension and bradycardia in rats, follow
Sequence CXRHXRWGC(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)
Action Type ANTAGONIST
Mechanism of action Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

Associated Targets(Human)

MC5R Tchem Melanocortin receptor 5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC4R Tclin Melanocortin receptor 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC3R Tchem Melanocortin receptor 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC1R Tclin Melanocyte-stimulating hormone receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

Storage Temp Store at -20°C,Desiccated
Shipped In Ice chest + Ice pads
CAS 212370-59-7(free base)

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
F2403035 Certificate of Analysis Feb 20, 2024 H288535
F2403038 Certificate of Analysis Feb 20, 2024 H288535
F2403039 Certificate of Analysis Feb 20, 2024 H288535
F2403041 Certificate of Analysis Feb 20, 2024 H288535
F2403036 Certificate of Analysis Feb 20, 2024 H288535
F2403037 Certificate of Analysis Feb 20, 2024 H288535
F2403040 Certificate of Analysis Feb 20, 2024 H288535
F2403042 Certificate of Analysis Feb 20, 2024 H288535

Genetic information

Alternate Names AKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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