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Small Molecules & Compound Libraries
Signaling Pathways
Cell Cycle/DNA Damage
Polo-like Kinase (PLK)
HMN-176 - 98%, high purity , CAS No.173529-10-7

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HMN-176 - 98%, high purity , CAS No.173529-10-7

COA

Grade & Purity:

≥98%

Cas Number: 173529-10-7
Molecular Weight: 382.43
PubChem CID: 12134997
PubChem SID: 504766925

In stock

Item Number

H413336

Grouped product items
SKU	Size	Availability	Price
H413336-5mg	5mg	3	$98.90
H413336-10mg	10mg	2	$147.90
H413336-25mg	25mg	2	$246.90
H413336-50mg	50mg	2	$444.90
H413336-100mg	100mg	2	$741.90

PLK Inhibitors

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Polo-like Kinase (PLK) (34)

Basic Description

Synonyms	SCHEMBL5173597 \| Benzenesulfonamide, 4-methoxy-N-(2-((1E)-2-(1-oxido-4-pyridinyl)ethenyl)phenyl)- \| YGA52910 \| HMN 176 \| (NE)-N-[(6E)-6-[2-(1-hydroxypyridin-4-ylidene)ethylidene]cyclohexa-2,4-dien-1-ylidene]-4-methoxybenzenesulfonamide \| (E)-4-((2-N-(4-Me
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	HMN-176 is an active metabolite of HMN-214, which has a potent antitumor activity in mouse xenograft models. HMN-176 effectively inhibits PLK-1 by interference with its normal subcellular spatial distribution at centrosomes and along the cytoskeletal stru
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information HMN-176 HMN-176 is an active metabolite of HMN-214, which has a potent antitumor activity in mouse xenograft models. HMN-176 effectively inhibits PLK-1 by interference with its normal subcellular spatial distribution at centrosomes and along the cytoskeletal structure.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	Benzenesulfonyl compounds Phenoxy compounds Methoxybenzenes Anisoles Dihydropyridines Alkyl aryl ethers Sulfonyls Organosulfonic acids and derivatives N-organohydroxylamines Azacyclic compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzenesulfonamide - Benzenesulfonyl group - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Dihydropyridine - Hydropyridine - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - N-organohydroxylamine - Azacycle - Ether - Organoheterocyclic compound - Organic nitrogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.292
HBD Count	1
Rotatable Bond	6

Names and Identifiers

Pubchem Sid	504766925
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766925
IUPAC Name	(NE)-N-[(6E)-6-[2-(1-hydroxypyridin-4-ylidene)ethylidene]cyclohexa-2,4-dien-1-ylidene]-4-methoxybenzenesulfonamide
INCHI	InChI=1S/C20H18N2O4S/c1-26-18-8-10-19(11-9-18)27(24,25)21-20-5-3-2-4-17(20)7-6-16-12-14-22(23)15-13-16/h2-15,23H,1H3/b17-7+,21-20+
InChIKey	MYEJOKLXXLVMPR-STNHEDLKSA-N
Smiles	COC1=CC=C(C=C1)S(=O)(=O)N=C2C=CC=CC2=CC=C3C=CN(C=C3)O
Isomeric SMILES	COC1=CC=C(C=C1)S(=O)(=O)/N=C/2\C=CC=C\C2=C/C=C3C=CN(C=C3)O
PubChem CID	12134997
Molecular Weight	382.43

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
K2223495	Certificate of Analysis	Jul 23, 2022	H413336
K2223502	Certificate of Analysis	Jul 23, 2022	H413336
K2223501	Certificate of Analysis	Jul 23, 2022	H413336
K2223500	Certificate of Analysis	Jul 23, 2022	H413336
K2223499	Certificate of Analysis	Jul 23, 2022	H413336

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 76 mg/mL (198.72 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	76
DMSO(mM) Max Solubility	198.729179196193
Water(mg / mL) Max Solubility	＜1
Molecular Weight	382.400 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	382.099 Da
Monoisotopic Mass	382.099 Da
Topological Polar Surface Area	87.600 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	846.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	2
Covalently-Bonded Unit Count	1

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