HLY78, a Lycorine ( HY-N0288 ) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylat
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Product Description
HLY78, a Lycorine derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research
In Vitro
HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway. HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls. HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells. HLY78 significantly increases TNKS expression, which is ameliorated by Dihydroartemisinin . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
HLY78 (0-1.8 mg/kg, Intranasal injection, once) attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH (subarachnoid hemorrhage) in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Sprague-Dawley rats (280-310 g, n=9/group, SAH model)Dosage: 0, 0.2, 0.6, and 1.8 mg/kg Administration: Intranasal injection, once, at 1 h post-SAH (subarachnoid hemorrhage) Result: Significantly attenuated the short-term and long-term neurobehavioral deficits, as well as the neuronal apoptosis after SAH at 0.6 mg/kg. Successfully delivered into the brain via intranasal administration at 0.6 mg/kg and was sufficient to significantly increase the phosphorylation of LRP6. Reversed the changes of the Bcl-2, Bax, and cleaved caspase 3 levels.
IC50& Target:Wnt/β-catenin
Names and Identifiers
Smiles
CCC1=C2C(=CC=C1)C3=CC4=C(C=C3CN2C)OCO4
Molecular Weight
267.32
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