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HLY78 - 98%, high purity , CAS No.854847-61-3

COA

Grade & Purity:

≥98%

Cas Number: 854847-61-3
Molecular Weight: 267.32
PubChem CID: 44422459

In stock

Item Number

H651654

Grouped product items
SKU	Size	Availability	Price
H651654-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90
H651654-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$160.90
H651654-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$310.90
H651654-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$500.90
H651654-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90

View related series

Apoptosis (4276) Stem Cell/Wnt (1019) Wnt (104) β-catenin (56)

Basic Description

Synonyms	AKOS037643437 \| SCHEMBL15995588 \| 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine \| A900672 \| AC-36980 \| 4-ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenanthridine \| HLY78 \| HLY-78 \| 4-Ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenant
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	HLY78, a Lycorine ( HY-N0288 ) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylat
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	HLY78, a Lycorine derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research In Vitro HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway. HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls. HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells. HLY78 significantly increases TNKS expression, which is ameliorated by Dihydroartemisinin . MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo HLY78 (0-1.8 mg/kg, Intranasal injection, once) attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH (subarachnoid hemorrhage) in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Sprague-Dawley rats (280-310 g, n=9/group, SAH model)Dosage: 0, 0.2, 0.6, and 1.8 mg/kg Administration: Intranasal injection, once, at 1 h post-SAH (subarachnoid hemorrhage) Result: Significantly attenuated the short-term and long-term neurobehavioral deficits, as well as the neuronal apoptosis after SAH at 0.6 mg/kg. Successfully delivered into the brain via intranasal administration at 0.6 mg/kg and was sufficient to significantly increase the phosphorylation of LRP6. Reversed the changes of the Bcl-2, Bax, and cleaved caspase 3 levels. Form:Solid IC50& Target:Wnt/β-catenin

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Benzoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Benzoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Phenanthridines and derivatives
Alternative Parents	Benzodioxoles Dialkylarylamines Aralkylamines Benzenoids Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenanthridine - Benzodioxole - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aralkylamine - Benzenoid - Tertiary amine - Acetal - Oxacycle - Azacycle - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenanthridines and derivatives. These are polycyclic compounds containing a phenanthridine moiety, which is a tricyclic system with two benzene rings joined by a pyridine forming a non-linear skeleton. Hydrogenated derivatives are also included.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-ethyl-5-methyl-6H-[1,3]dioxolo[4,5-j]phenanthridine
INCHI	InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3
InChIKey	FAZZYPIBZBGQSH-UHFFFAOYSA-N
Smiles	CCC1=C2C(=CC=C1)C3=CC4=C(C=C3CN2C)OCO4
Isomeric SMILES	CCC1=C2C(=CC=C1)C3=CC4=C(C=C3CN2C)OCO4
WGK Germany	3
PubChem CID	44422459
Molecular Weight	267.32

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 26 mg/mL (97.26 mM; Need ultrasonic)
Molecular Weight	267.320 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	267.126 Da
Monoisotopic Mass	267.126 Da
Topological Polar Surface Area	21.700 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	361.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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