Skip to the beginning of the images gallery

HIOC - ≥98%(HPLC), high purity , CAS No.314054-36-9

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 314054-36-9
Molecular Weight: 301.34
PubChem CID: 5012758

In stock

Item Number

H287399

Grouped product items
SKU	Size	Availability	Price
H287399-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$108.90
H287399-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90
H287399-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$378.90
H287399-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$679.90

Selective TrkB receptor agonist; neuroprotectant

View related series

Apoptosis (4276) ERK (132) MAPK/ERK Pathway (546) Neuronal Signaling (3320) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) Stem Cell/Wnt (1019) Trk Receptor (42)

Basic Description

Synonyms	N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide \| Oprea1_857764 \| HIOC \| CCG-15049 \| SCHEMBL17913885 \| N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)-2-oxo-3-piperidinecarboxamide \| Oprea1_263218 \| JC3KZQ72GW \| HY-101446 \| UNII-JC3KZQ72GW \| AKOS0
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD)in vivo. Blood brain barrier and blood-retinal barrier penetrant.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Tryptamines and derivatives
      - Level5 Serotonins
        Level6 N-acylserotonins

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Tryptamines and derivatives
Intermediate Tree Nodes	Serotonins
Direct Parent	N-acylserotonins
Alternative Parents	Hydroxyindoles 3-alkylindoles Piperidinecarboxamides Piperidinones Delta lactams 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles 1,3-dicarbonyl compounds Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-acylserotonin - Hydroxyindole - 3-alkylindole - Indole - 3-piperidinecarboxamide - Piperidinecarboxamide - Delta-lactam - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Piperidinone - Piperidine - Benzenoid - 1,3-dicarbonyl compound - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Lactam - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-acylserotonins. These are aromatic heterocyclic compounds containing a serotonin, in which the amine group is acylated.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide
INCHI	InChI=1S/C16H19N3O3/c20-11-3-4-14-13(8-11)10(9-19-14)5-7-18-16(22)12-2-1-6-17-15(12)21/h3-4,8-9,12,19-20H,1-2,5-7H2,(H,17,21)(H,18,22)
InChIKey	ZIMKJLALTRLXJO-UHFFFAOYSA-N
Smiles	C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O
Isomeric SMILES	C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O
Molecular Weight	301.34
Reaxy-Rn	26247052
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26247052&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 30.13, Max Conc. mM: 100
Sensitivity	heat sensitive；Moisture sensitive
Molecular Weight	301.340 g/mol
XLogP3	1.000
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	301.143 Da
Monoisotopic Mass	301.143 Da
Topological Polar Surface Area	94.200 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	429.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration