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HIF-2α-IN-8 - 99%, high purity , CAS No.2734922-78-0

COA

Grade & Purity:

≥99%

Cas Number: 2734922-78-0
Molecular Weight: 441.73

In stock

Item Number

H647047

Grouped product items
SKU	Size	Availability	Price
H647047-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
H647047-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$880.90
H647047-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90

View related series

Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC 50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC 50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity In Vivo HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model) Dosage: 30 mg/kg Administration: P.o.; started 34 days post tumor inoculation; daily for 21 days Result: Inhibited the tumor growth. Form:Solid IC50& Target:IC 50 : 9 nM (HIF2α SPA),37 nM (HIF2α iScript),246 nM (HIF2α HRE RGA)

Names and Identifiers

Smiles	FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F
Molecular Weight	441.73

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