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HIF-1α-IN-2 , CAS No.2762315-06-8

COA

Cas Number: 2762315-06-8
Molecular Weight: 361.46

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Item Number

H650287

Grouped product items
SKU	Size	Availability	Price
H650287-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
H650287-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$280.90
H650287-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$520.90
H650287-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90
H650287-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90

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Basic Description

Biochemical and Physiological Mechanisms	HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies ( IC 50 s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2xa0suppresses HIF-1α expression by blocking transcription andxa0protein translation.
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies ( IC 50 s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation In Vitro HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC 50 s of 28 nM and 15 nM, respectively. HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect. HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2. HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay Cell Line: MDA-MB-231 cells, MiaPaCa-2 cellsConcentration: 5 μM Incubation Time: 72 hours Result: Suppressed the viability of these two cell lines with IC 50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. Cell Viability Assay Cell Line: MDA-MB-231 cells, MiaPaCa-2 cellsConcentration: 5 μM Incubation Time: 72 hours Result: Suppressed the viability of these two cell lines with IC 50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. Form:Solid IC50& Target:IC 50 : 28 nM (HIF-1α) in MDA-MB-231, 15 nM (HIF-1α) in MiaPaCa-2

Names and Identifiers

Smiles	CC1=NC(C2=CC(NC3=CC(C)=NC4=CC(OC)=CC=C34)=CC=C2)=CS1
Molecular Weight	361.46

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