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HI TOPK 032 - 98%, high purity , CAS No.487020-03-1

COA

Grade & Purity:

≥98%

Cas Number: 487020-03-1
Molecular Weight: 369.4
PubChem CID: 1936439
PubChem SID: 488192023

In stock

Item Number

H288486

Grouped product items
SKU	Size	Availability	Price
H288486-5mg	5mg	3	$77.90
H288486-10mg	10mg	2	$116.90
H288486-25mg	25mg	1	$253.90
H288486-50mg	50mg	1	$436.90
H288486-100mg	100mg	1	$757.90

Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) TOPK (10)

Basic Description

Synonyms	SCHEMBL15270774 \| NCGC00379159-05 \| 2-Thiophenecarboxamide, N-(12-cyanoindolizino(2,3-b)quinoxalin-2-yl)- \| N-(12-Cyanoindolizino(2,3-b)quinoxalin-2-yl)-2-thiophenecarboxamide \| HI TOPK 032 \| N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)thiophene-2-carboxa
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Product description： HI-TOPK-032 is a potent and specific TOPK inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazanaphthalenes
    - Subclass Benzodiazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes
Subclass	Benzodiazines
Intermediate Tree Nodes	Not available
Direct Parent	Quinoxalines
Alternative Parents	Pyrrolopyrazines Indolizines Thiophene carboxamides 2-heteroaryl carboxamides Substituted pyrroles Pyridines and derivatives Pyrazines Benzenoids Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Nitriles Hydrocarbon derivatives Organic oxides Organooxygen compounds Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoxaline - Indolizine - Pyrrolopyrazine - Pyrrolopyridine - 2-heteroaryl carboxamide - Thiophene carboxylic acid or derivatives - Thiophene carboxamide - Pyrazine - Pyridine - Benzenoid - Substituted pyrrole - Pyrrole - Heteroaromatic compound - Thiophene - Carboxamide group - Secondary carboxylic acid amide - Nitrile - Carbonitrile - Carboxylic acid derivative - Azacycle - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488192023
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488192023
IUPAC Name	N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)thiophene-2-carboxamide
INCHI	InChI=1S/C20H11N5OS/c21-11-13-16-10-12(22-20(26)17-6-3-9-27-17)7-8-25(16)19-18(13)23-14-4-1-2-5-15(14)24-19/h1-10H,(H,22,26)
InChIKey	BCSBXWKRZUPFHW-UHFFFAOYSA-N
Smiles	C1=CC=C2C(=C1)N=C3C(=C4C=C(C=CN4C3=N2)NC(=O)C5=CC=CS5)C#N
Isomeric SMILES	C1=CC=C2C(=C1)N=C3C(=C4C=C(C=CN4C3=N2)NC(=O)C5=CC=CS5)C#N
Molecular Weight	369.4
Reaxy-Rn	24124471
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24124471&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
E2315892	Certificate of Analysis	Mar 20, 2023	H288486
E2315932	Certificate of Analysis	Mar 20, 2023	H288486
E2315875	Certificate of Analysis	Mar 20, 2023	H288486
E2315922	Certificate of Analysis	Mar 20, 2023	H288486
E2315928	Certificate of Analysis	Mar 20, 2023	H288486
E2315305	Certificate of Analysis	Mar 20, 2023	H288486
E2315284	Certificate of Analysis	Mar 20, 2023	H288486
E2315288	Certificate of Analysis	Mar 20, 2023	H288486
E2315303	Certificate of Analysis	Mar 20, 2023	H288486
E2315884	Certificate of Analysis	Mar 20, 2023	H288486

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 7.39, Max Conc. mM: 20
Molecular Weight	369.400 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	369.068 Da
Monoisotopic Mass	369.068 Da
Topological Polar Surface Area	111.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	635.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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