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Small Molecules & Compound Libraries
Signaling Pathways
Protein Tyrosine Kinase/RTK
Anaplastic lymphoma kinase (ALK)
HG-14-10-04 - 98%, high purity , CAS No.1356962-34-9

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HG-14-10-04 - 98%, high purity , CAS No.1356962-34-9

COA

Grade & Purity:

≥98%

Cas Number: 1356962-34-9
Molecular Weight: 532.08
PubChem CID: 56655374
PubChem SID: 504771434

In stock

Item Number

H413495

Grouped product items
SKU	Size	Availability	Price
H413495-1mg	1mg	3	$46.90
H413495-2mg	2mg	3	$78.90
H413495-5mg	5mg	2	$162.90
H413495-25mg	25mg	2	$435.90
H413495-100mg	100mg	2	$706.90

ALK Inhibitors

View related series

Anaplastic lymphoma kinase (ALK) (52) EGFR (254) JAK/STAT Signaling (507) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	A906951 \| AC-36124 \| HY-15801 \| HG141004 \| HG-14-10-04 \| 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine \| MS-29833 \| 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperid
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	HG-14-10-04 is an inhibitor of ALK.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information HG-14-10-04 HG-14-10-04 is an inhibitor of ALK . Targets ALK

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines
    - Subclass Phenylpiperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Phenylpiperidines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpiperidines
Alternative Parents	Indoles Methoxyanilines Aminophenyl ethers Anisoles Dialkylarylamines Methoxybenzenes Phenoxy compounds Aminopiperidines Halopyrimidines Aminopyrimidines and derivatives N-methylpiperazines Alkyl aryl ethers Aryl chlorides Substituted pyrroles Heteroaromatic compounds Trialkylamines Secondary amines Azacyclic compounds Hydrocarbon derivatives Organochlorides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenylpiperidine - Aminophenyl ether - Indole or derivatives - Indole - Methoxyaniline - Tertiary aliphatic/aromatic amine - Phenoxy compound - Phenol ether - Anisole - Methoxybenzene - Aniline or substituted anilines - Dialkylarylamine - Halopyrimidine - N-alkylpiperazine - N-methylpiperazine - Aminopyrimidine - 4-aminopiperidine - Alkyl aryl ether - Aryl chloride - Aryl halide - Monocyclic benzene moiety - 1,4-diazinane - Benzenoid - Piperazine - Pyrimidine - Substituted pyrrole - Pyrrole - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Secondary amine - Azacycle - Ether - Amine - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Organohalogen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	5.241
hba_count	3
HBD Count	2
Rotatable Bond	6

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504771434
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771434
IUPAC Name	5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine
INCHI	InChI=1S/C29H34ClN7O/c1-35-13-15-37(16-14-35)20-9-11-36(12-10-20)21-7-8-26(27(17-21)38-2)33-29-32-19-24(30)28(34-29)23-18-31-25-6-4-3-5-22(23)25/h3-8,17-20,31H,9-16H2,1-2H3,(H,32,33,34)
InChIKey	HRYNCLKDKCPYBF-UHFFFAOYSA-N
Smiles	CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)C5=CNC6=CC=CC=C65)Cl)OC
Isomeric SMILES	CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)C5=CNC6=CC=CC=C65)Cl)OC
Molecular Weight	532.08
Reaxy-Rn	22168451
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22168451&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
I2205153	Certificate of Analysis	Jun 09, 2025	H413495
I2205197	Certificate of Analysis	Jun 09, 2025	H413495
I2205154	Certificate of Analysis	Jun 09, 2025	H413495
I2205198	Certificate of Analysis	Jun 09, 2025	H413495
I2205155	Certificate of Analysis	Jun 09, 2025	H413495

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 10 mg/mL (18.79 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	10
DMSO(mM) Max Solubility	18.7941662907833
Water(mg / mL) Max Solubility	＜1
Molecular Weight	532.100 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	531.251 Da
Monoisotopic Mass	531.251 Da
Topological Polar Surface Area	72.600 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	746.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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