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Hesperidin - 97%, high purity , CAS No.520-26-3

    Grade & Purity:
  • ≥97%
In stock
Item Number
H105437
Grouped product items
SKU Size
Availability
Price Qty
H105437-5g
5g
4
$13.90
H105437-10g
10g
5
$21.90
H105437-25g
25g
3
$41.90
H105437-100g
100g
1
$120.90
H105437-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$542.90

Flavonoid

Basic Description

Synonyms (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | CHEBI:28775 | DIOSVEIN | EINECS 208-288-1 | Hesperetin 7 Rhamnoglucoside | Q385937 | D01038 | hesperidin | DTXSID9
Specifications & Purity ≥97%
Biochemical and Physiological Mechanisms Flavonoid phytochemical extracted from citrus species. It is the rhamnoglucoside of hesperetin.Flavonoid. Shows anti-oxidant, antibacterial and anti-inflammatory activites. A potent chemopreventive agent.
Storage Temp Store at 2-8°C,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Flavonoids
Subclass Flavonoid glycosides
Intermediate Tree Nodes Flavonoid O-glycosides
Direct Parent Flavonoid-7-O-glycosides
Alternative Parents 4'-O-methylated flavonoids  3'-hydroxyflavonoids  5-hydroxyflavonoids  Flavanones  Phenolic glycosides  O-glycosyl compounds  Disaccharides  Chromones  Methoxyphenols  Phenoxy compounds  Methoxybenzenes  Anisoles  Aryl alkyl ketones  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Oxanes  Vinylogous acids  Secondary alcohols  Acetals  Oxacyclic compounds  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Flavonoid-7-o-glycoside - 4p-methoxyflavonoid-skeleton - 3'-hydroxyflavonoid - 5-hydroxyflavonoid - Flavanone - Hydroxyflavonoid - Flavan - Phenolic glycoside - Chromone - Disaccharide - Glycosyl compound - O-glycosyl compound - Chromane - Benzopyran - Methoxyphenol - 1-benzopyran - Phenoxy compound - Anisole - Methoxybenzene - Aryl alkyl ketone - Aryl ketone - Phenol ether - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Oxane - Vinylogous acid - Secondary alcohol - Ketone - Acetal - Organoheterocyclic compound - Ether - Oxacycle - Polyol - Alcohol - Organooxygen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as flavonoid-7-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position.
External Descriptors flavanones

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FABP4 Tchem Fatty acid binding protein adipocyte (764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPSE Tchem Heparanase (634 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caco-2 (12174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DLD-1 (17511 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
H9 (1832 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Monocyte (474 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL (112 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTDSP1 Tchem Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (1031 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CACNA1B Tclin Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 (925 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Chlamydia pneumoniae (241 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
3T3-L1 (3664 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF S-180 (1031 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L1210 (27553 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CALM Calmodulin (71 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slco1a5 Solute carrier organic anion transporter family member 1A5 (48 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
INCHI InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChIKey QUQPHWDTPGMPEX-QJBIFVCTSA-N
Smiles COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
WGK Germany 3
Molecular Weight 610.56
Beilstein 75140

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number Certificate Type Date Item
G2326635 Certificate of Analysis Aug 01, 2023 H105437
G2326778 Certificate of Analysis Aug 01, 2023 H105437
G2326770 Certificate of Analysis Aug 01, 2023 H105437
G2326658 Certificate of Analysis Aug 01, 2023 H105437
G2326637 Certificate of Analysis Aug 01, 2023 H105437
G2326639 Certificate of Analysis Aug 01, 2023 H105437
G2326653 Certificate of Analysis Aug 01, 2023 H105437
G23261477 Certificate of Analysis Aug 01, 2023 H105437
G23261483 Certificate of Analysis Aug 01, 2023 H105437
D2525005 Certificate of Analysis Aug 01, 2023 H105437
F2320032 Certificate of Analysis Jul 04, 2023 H105437
C2218302 Certificate of Analysis Mar 23, 2022 H105437
C2218287 Certificate of Analysis Mar 23, 2022 H105437
C2218305 Certificate of Analysis Mar 23, 2022 H105437
C2218271 Certificate of Analysis Mar 23, 2022 H105437

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Chemical and Physical Properties

Sensitivity Air sensitive
Melt Point(°C) 250-255°C
Molecular Weight 610.600 g/mol
XLogP3 -1.100
Hydrogen Bond Donor Count 8
Hydrogen Bond Acceptor Count 15
Rotatable Bond Count 7
Exact Mass 610.19 Da
Monoisotopic Mass 610.19 Da
Topological Polar Surface Area 234.000 Ų
Heavy Atom Count 43
Formal Charge 0
Complexity 940.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 11
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Min-Rui Tai, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong, Aaqil Rifai, David R. Nisbet, Colin J. Barrow, Richard J. Williams, Rui Li.  (2023)  Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  251  (126232). 
2. Hong-Qi Xia, Wanbing Chen, Diyang Qiu, Jiwu Zeng.  (2023)  Portable Microelectrochemical Sensors for Rapid and Sensitive Determination of Hesperidin in Citrus reticulate ‘Chachi’ Peel.  MOLECULES,  28  (14): (5316). 
3. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu.  (2023)  Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey.  Food Chemistry-X,  19  (100766). 
4. Shengxiang Yi, Gaowei Zhang, Mingyan Liu, Wenjie Yu, Guohua Cheng, Liping Luo, Fangjian Ning.  (2023)  Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice.  Nutrients,  15  (5): (1078). 
5. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong.  (2023)  Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation.  Frontiers in Microbiology,  14   
6. Hong-qi Xia, Diyang Qiu, Wanbing Chen, Genlin Mao, Jiwu Zeng.  (2023)  In situ formed and fully integrated laser-induced graphene electrochemical chips for rapid and simultaneous determination of bioflavonoids in citrus fruits.  MICROCHEMICAL JOURNAL,  188  (108474). 
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li.  (2023)  Stability and antioxidant activity of phenolic compounds during in vitro digestion.  JOURNAL OF FOOD SCIENCE,  88  (2): (696-716). 
8. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo.  (2023)  Chemical composition and anti-inflammatory activities of Castanopsis honey.  Food & Function,  14  (1): (250-261). 
9. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting.  (2022)  Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling.  AMB Express,  12  (1): (1-14). 
10. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang.  (2023)  Municipal green waste promotes iron release from steelmaking slag in water.  RESOURCES CONSERVATION AND RECYCLING,  188  (106722). 
11. Qi Quan, Wei Liu, Jiajing Guo, Meiling Ye, Juhua Zhang.  (2022)  Effect of Six Lactic Acid Bacteria Strains on Physicochemical Characteristics, Antioxidant Activities and Sensory Properties of Fermented Orange Juices.  Foods,  11  (13): (1920). 
12. Ye Hangyu, Li Xiaojun, Li Luyuan, Zhang Yinjun, Zheng Jianyong.  (2022)  Homologous Expression and Characterization of α-L-rhamnosidase from Aspergillus niger for the Transformation of Flavonoids.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,  194  (8): (3453-3467). 
13. Hong-qi Xia, Tingting Gu, Ruiyi Fan, Jiwu Zeng.  (2022)  Comparative investigation of bioflavonoid electrocatalysis in 1D, 2D, and 3D carbon nanomaterials for simultaneous detection of naringin and hesperidin in fruits.  RSC Advances,  12  (11): (6409-6415). 
14. Xiangrong Li, Ruonan Xu, Zeqing Cheng, Zhizhi Song, Ziyang Wang, Hanxiao Duan, Xinzhe Wu, Tianjun Ni.  (2021)  Comparative study on the interaction between flavonoids with different core structures and hyaluronidase.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  262  (120079). 
15. Dan-Hua He, Yu-Fei Chen, Yi-Le Zhou, Shi-Bing Zhang, Ming Hong, Xianjun Yu, Su-Fen Wei, Xiang-Zhen Fan, Si-Yi Li, Qi Wang, Yongzhi Lu, Yong-Qiang Liu.  (2021)  Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non–small cell lung cancer.  CANCER SCIENCE,  112  (8): (3218-3232). 
16. Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang.  (2021)  Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities.  LWT-FOOD SCIENCE AND TECHNOLOGY,  147  (111671). 
17. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng.  (2020)  Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis.  EUROPEAN FOOD RESEARCH AND TECHNOLOGY,  246  (10): (1909-1918). 
18. Hui Guo, Yunfei Chen, Na Song, Xinyi Yang, Shen Yao, Junqing Qian.  (2020)  Screening of lipase inhibitors from bamboo leaves based on the magnetic ligand fishing combined with HPLC/MS.  MICROCHEMICAL JOURNAL,  153  (104497). 
19. Xinlin Chen, Shang Xue, Yaolan Lin, Jianguang Luo, Lingyi Kong.  (2020)  Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs.  ANALYTICA CHIMICA ACTA,  1099  (94). 
20. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.  (2019)  Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies.  Foods,  (9): (355). 
21. Xuexue Feng, Tielei Wu, Bingqing Yu, Yan Wang, Shian Zhong.  (2017)  Hydrophilic surface molecularly imprinted naringin prepared via reverse atom transfer radical polymerization with excellent recognition ability in a pure aqueous phase.  RSC Advances,  (45): (28082-28091). 
22. Songbai Liu, Yuanqing Fu, Si Nian.  (2014)  Buffering colour fluctuation of purple sweet potato anthocyanins to acidity variation by surfactants.  FOOD CHEMISTRY,  162  (16). 
23. Shi Shen,Jingbo Wang,Qin Zhuo,Xi Chen,Tingting Liu,Shuang-Qing Zhang.  (2018-05-09)  Quantitative and Discriminative Evaluation of Contents of Phenolic and Flavonoid and Antioxidant Competence for Chinese Honeys from Different Botanical Origins..  Molecules (Basel, Switzerland),  23  ((5)):  
24. Sisi Ke, Ningrui Wang, Xingyu Chen, Jiangwei Tian, Jiwei Li, Boyang Yu.  (2025)  A Label-Free Colorimetric Aptasensor for Flavokavain B Detection.  SENSORS,  25  (2): (569). 

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