Basic Description

Specifications & Purity	≥95%, Potency:<10IU/mg
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Heparan Sulfate (HS) is a class of sulfated GAGs composed of disaccharide units (GlcUA/IdoUA β/α 1-4GlcNAc) composed of glucuronic acid (GlcUA)/iduronic acid (IdoUA) and N-acetylglucosamine (GlcNAc), which are repeatedly linked by α -1,4-glycosidic bonds. In biosynthesis, HS covalently binds to core proteins to form proteoglycans (HSPGs), which are widely expressed on the cell surface and extracellular matrix; GlcUA can undergo differential isomerization to form IdoUA, and under the action of various sulfate transferases, the N, C6, and C3 positions of GlcNAc and the C2 position of GlcUA in the HS chain are sulfated to form highly complex HS side chains. Compared with heparin (Hep), HS has a more complex structure, manifested by more diverse sulfurization modes, lower IdoA content, and longer polysaccharide chains. The HS polysaccharide chain can be roughly divided into three parts: the NA region, which is the region without sulfation modification; In the NS region, the GlcNAc residues in the disaccharide units have undergone deacetylation and sulfation modifications; The NA/NS region is a mixed region of NA and NS, where many sulfation and isomerization modifications in HS occur. HS participates in various physiological and pathological processes such as growth, development, and disease occurrence through interactions with growth factors, cytokines, matrix proteins, etc.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Fatty Acyls
    - Subclass Fatty acyl glycosides

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Fatty Acyls
Subclass	Fatty acyl glycosides
Intermediate Tree Nodes	Not available
Direct Parent	Fatty acyl glycosides of mono- and disaccharides
Alternative Parents	O-glucuronides Sulfated fatty acids Short-chain hydroxy acids and derivatives Hydroxy fatty acids Heterocyclic fatty acids Sulfuric acid monoesters Sulfuric acid monoamides Pyrans Oxanes Monosaccharides Dicarboxylic acids and derivatives Alkyl sulfates Secondary alcohols Oxacyclic compounds Dialkyl ethers Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Organic anions
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Fatty acyl glycoside of mono- or disaccharide - O-glucuronide - 1-o-glucuronide - Glucuronic acid or derivatives - Sulfated fatty acid - Short-chain hydroxy acid - Hydroxy fatty acid - Heterocyclic fatty acid - Fatty acid - Sulfuric acid ester - Alkyl sulfate - Sulfate-ester - Sulfuric acid monoester - Pyran - Oxane - Sulfuric acid monoamide - Monosaccharide - Dicarboxylic acid or derivatives - Organic sulfuric acid or derivatives - Secondary alcohol - Oxacycle - Organoheterocyclic compound - Ether - Dialkyl ether - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Alcohol - Organic anion - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as fatty acyl glycosides of mono- and disaccharides. These are compounds composed of a mono- or disaccharide moiety linked to one hydroxyl group of a fatty alcohol or of a phosphorylated alcohol (phosphoprenols), a hydroxy fatty acid or to one carboxyl group of a fatty acid (ester linkage) or to an amino alcohol.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	azane;(3R,4R,5S,6R)-3-[(2S,3S,4R,5R)-5-[(2R,3S,4S,5R)-6-carboxylato-4-hydroxy-5-methoxy-3-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-3-(sulfonatoamino)-6-(sulfonatooxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-[(3S,4R,5S,6R)-6-methoxy-5-(sulfonatoamino)-4-sulfonatooxy-2-(sulfonatooxymethyl)oxan-3-yl]oxyoxane-2-carboxylate
INCHI	InChI=1S/C26H44N2O39S6.H3N/c1-55-16-12(32)18(67-73(52,53)54)26(65-19(16)21(33)34)61-13-5(3-57-70(43,44)45)60-24(7(9(13)29)27-68(37,38)39)63-17-10(30)11(31)25(64-20(17)22(35)36)62-14-6(4-58-71(46,47)48)59-23(56-2)8(28-69(40,41)42)15(14)66-72(49,50)51;/h5-20,23-32H,3-4H2,1-2H3,(H,33,34)(H,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);1H3/p-8/t5?,6?,7-,8-,9+,10+,11-,12-,13-,14-,15+,16+,17+,18-,19?,20?,23+,24-,25+,26+;/m0./s1
InChIKey	XSIDRQZFWFCLLF-VYLUHDBLSA-F
Smiles	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2O)NS(=O)(=O)[O-])OC3C(C(C(OC3C(=O)[O-])OC4C(OC(C(C4OS(=O)(=O)[O-])NS(=O)(=O)[O-])OC)COS(=O)(=O)[O-])O)O)COS(=O)(=O)[O-])OS(=O)(=O)[O-])O.N
Isomeric SMILES	CO[C@@H]1[C@@H]([C@@H]([C@@H](OC1C(=O)[O-])O[C@@H]2[C@@H]([C@@H]([C@@H](OC2COS(=O)(=O)[O-])O[C@@H]3[C@@H]([C@@H]([C@@H](OC3C(=O)[O-])O[C@@H]4[C@@H]([C@@H]([C@@H](OC4COS(=O)(=O)[O-])OC)NS(=O)(=O)[O-])OS(=O)(=O)[O-])O)O)NS(=O)(=O)[O-])O)OS(=O)(=O)[O-])O.N
PubChem CID	137699201
Molecular Weight	593.47 (monomer)

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Methanol (Slightly), Water (Slightly)
Sensitivity	Moisture sensitive.
Melt Point(°C)	>216°C (dec.)

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiahua Duan, Gaofei Qian, Huikang Zhang, Feifan Wang, Qiang Tian, Dong Lei, Jianning Zhao. (2025) 3D-Printed Biomimetic Vascular Scaffold Crosslinked with Heparan Sulfate for Sustained Release of PDGFB-LG4 Fusion Protein Promotes Bone Regeneration. Advanced Science, (2414362).
2. Jianjian Ji, Yingcai Xiong, Keyu Tao, Tao Li, Weiying Ou, Yinghui Zhou, Wenyang Zhang, Ruogu Qi, Shouchuan Wang. (2024) Resveratrol inhibits respiratory syncytial virus replication by targeting heparan sulfate proteoglycan. Food & Function,

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SKU	Size	Availability	Price	Qty
H758204-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90
H758204-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,333.90

Heparan Sulfate - ≥95%, Potency: