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HeE1-2Tyr - 96%, high purity , CAS No.2245195-67-7

COA

Grade & Purity:

≥96%

Cas Number: 2245195-67-7
Molecular Weight: 582.67

In stock

Item Number

H649577

Grouped product items
SKU	Size	Availability	Price
H649577-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
H649577-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
H649577-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
H649577-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90

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Anti-infection (2803) SARS-CoV (200) Virus (1811)

Basic Description

Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro In Vitro HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC 50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC 50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM. Additionally, upon infection of human HEK 293 cells (CC 50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC 50 values ranging from 3.9 to 12 µM. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Flavivirus RNA dependent RNA polymerases (RdRp), SARS-CoV-2 RdRps>

Names and Identifiers

Smiles	OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(C(C=C2C3=CC=CC=C3)=C4SC5=CC=C(OC6CCCCC6)C=C5N4C2=O)=O
Molecular Weight	582.67

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