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Halofuginone hydrobromide - ≥98%(HPLC), high purity , CAS No.64924-67-0

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
H288889
Grouped product items
SKU Size
Availability
 Price Qty
H288889-5mg
5mg
3
$88.90
H288889-25mg
25mg
2
$276.90
H288889-50mg
50mg
2
$498.90
H288889-100mg
100mg
2
$897.90
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High affinity competitive prolyl-tRNA synthetase inhibitor

View related series
Anti-infection (2803) Calcium Channel (223) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362) Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) Parasite (997) Sodium Channel (211) Stem Cell/Wnt (1019) TGF-beta/Smad (303)

Basic Description

Synonyms MFCD00017259 | RU-19110 (hydrobromide) | Halofuginone hydrobromide, (-)- | AMY26820 | HY-N1584A | AKOS015920268 | Halofuginonehydrobromide | Halofuginone (hydrobromide) | 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-,
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms High affinity competitive prolyl-tRNA synthetase inhibitor (Ki= 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasionin vitroand lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazanaphthalenes
Subclass Benzodiazines
Intermediate Tree Nodes Not available
Direct Parent Quinazolines
Alternative Parents Pyrimidones  Piperidines  Aryl bromides  Aryl chlorides  Benzenoids  Beta-amino ketones  Heteroaromatic compounds  Secondary alcohols  1,2-aminoalcohols  Lactams  Azacyclic compounds  Dialkylamines  Hydrobromides  Hydrocarbon derivatives  Organic oxides  Organobromides  Organochlorides  Organopnictogen compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinazoline - Pyrimidone - Piperidine - Pyrimidine - Aryl bromide - Benzenoid - Beta-aminoketone - Aryl halide - Aryl chloride - Heteroaromatic compound - Ketone - 1,2-aminoalcohol - Lactam - Secondary alcohol - Secondary amine - Secondary aliphatic amine - Azacycle - Organic nitrogen compound - Organochloride - Organobromide - Organohalogen compound - Organonitrogen compound - Organooxygen compound - Hydrobromide - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Alcohol - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
External Descriptors Not available

Associated Targets(Human)

A498 (42825 Activities)
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ACHN (49357 Activities)
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CAKI-1 (44928 Activities)
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CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
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DU-145 (51482 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MCF7 (126967 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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PC-3 (62116 Activities)
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RPMI-8226 (44974 Activities)
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RXF 393 (41971 Activities)
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SF-295 (48000 Activities)
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SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
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UACC-257 (46019 Activities)
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UO-31 (46270 Activities)
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786-0 (47912 Activities)
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A549 (127892 Activities)
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NCI/ADR-RES (33767 Activities)
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T47D (39041 Activities)
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EKVX (44102 Activities)
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NCI-H322M (45589 Activities)
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HCC 2998 (41480 Activities)
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HCT-116 (91556 Activities)
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HOP-92 (41141 Activities)
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Hs-578T (29457 Activities)
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NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
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IGROV-1 (47897 Activities)
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LOX IMVI (44321 Activities)
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HOP-62 (47048 Activities)
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MDA-MB-435 (38290 Activities)
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MDA-N (28205 Activities)
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Malme-3M (44254 Activities)
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MDA-MB-231 (73002 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide
INCHI InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/m0./s1
InChIKey SJUWEPZBTXEUMU-LDXVYITESA-N
Smiles C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
Isomeric SMILES C1C[C@H]([C@@H](NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
Molecular Weight 495.59
Reaxy-Rn 8956702
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8956702&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
K2111171 Certificate of Analysis Aug 21, 2024 H288889
K2111172 Certificate of Analysis Aug 21, 2024 H288889
K2111173 Certificate of Analysis Aug 21, 2024 H288889
K2111174 Certificate of Analysis Aug 21, 2024 H288889
L2418241 Certificate of Analysis Aug 21, 2024 H288889

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 49.56, Max Conc. mM: 100
Molecular Weight 495.600 g/mol
XLogP3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 4
Exact Mass 494.938 Da
Monoisotopic Mass 492.94 Da
Topological Polar Surface Area 82.000 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 533.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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