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HA 1100 hydrochloride (Hydroxyfasudil) - 98%, high purity , CAS No.155558-32-0

COA

Grade & Purity:

≥98%

Cas Number: 155558-32-0
Molecular Weight: 343.83
MDL number: MFCD06411567
PubChem CID: 11371328

In stock

Item Number

H275907

Grouped product items
SKU	Size	Availability	Price
H275907-10mg	10mg	2	$102.90
H275907-50mg	50mg	2	$187.90
H275907-100mg	100mg	2	$345.90

Selective, ATP-competitive, reversible Rho-kinase inhibitor

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Cytoskeleton (498) ROCK (71) Stem Cell/Wnt (1019) TGF-beta/Smad (303)

Basic Description

Synonyms	155558-32-0 (HCl salt) \| FD5036 \| H1745 \| HA 1100 hydrochloride \| SR-00000002171 \| 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride \| AKOS024457085 \| Hydroxy Fasudil Hydrochloride \| HB2293 \| BS-15717 \| HA-1100*hydrochloride \| Hydroxyfasudil (
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective, ATP-competitive, reversible Rho-kinase inhibitor (IC 50 values are 0.6 and 0.8 μM for Rock-1 and Rock-2, respectively). Cell-permeable active Fasudil metabolite.
Storage Temp	Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Isoquinolines and derivatives
    - Subclass Isoquinolones and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Isoquinolines and derivatives
Subclass	Isoquinolones and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Isoquinolones and derivatives
Alternative Parents	Pyridinones 1,4-diazepanes Organosulfonamides Benzenoids Sulfonyls Heteroaromatic compounds Lactams Dialkylamines Azacyclic compounds Organooxygen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Isoquinolone - 1,4-diazepane - Diazepane - Pyridinone - Pyridine - Benzenoid - Organosulfonic acid amide - Heteroaromatic compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Lactam - Secondary aliphatic amine - Azacycle - Secondary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Amine - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as isoquinolones and derivatives. These are aromatic polycyclic compounds containing a ketone bearing isoquinoline moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one;hydrochloride
INCHI	InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChIKey	XWWFOUVDVJGNNG-UHFFFAOYSA-N
Smiles	C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
Isomeric SMILES	C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
Molecular Weight	343.83
Reaxy-Rn	29628107
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29628107&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
I2202508	Certificate of Analysis	Jun 13, 2023	H275907
I2202507	Certificate of Analysis	Jun 13, 2023	H275907
I2202384	Certificate of Analysis	Jun 12, 2023	H275907

Chemical and Physical Properties

Solubility	Soluble in water to 25 mM
Sensitivity	Air Sensitive,Hygroscopic,Heat Sensitive
Melt Point(°C)	299 °C(dec.)
Molecular Weight	343.800 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	343.076 Da
Monoisotopic Mass	343.076 Da
Topological Polar Surface Area	86.900 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	526.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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