Skip to the beginning of the images gallery

H4R antagonist 1 - 98%, high purity , CAS No.1429375-54-1

COA

Grade & Purity:

≥98%

Cas Number: 1429375-54-1
Molecular Weight: 335.16
PubChem CID: 71548412

In stock

Item Number

H649780

Grouped product items
SKU	Size	Availability	Price
H649780-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$540.90
H649780-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$870.90
H649780-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,750.90

View related series

Class A GPCR (4138) GPCR/G Protein (3172) Histamine Receptor (191) Immunology/Inflammation (1929) Neuronal Signaling (3320)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	H4R antagonist 1 is a potent and highly selective histamine H4 receptor ( H4R ) antagonist with an IC 50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	H4R antagonist 1 is a potent and highly selective histamine H4 receptor ( H4R ) antagonist with an IC 50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R In Vitro The competitive binding assay against a wider panel of GPCR, ion channel, and transporters at the concentration of 10 μM reveals that H4R antagonist 1 (Compound 48) is highly selective for H4R. The inhibitory activity of H4R antagonist 1 against mouse H4R (IC 50 =0.29 μM) is about 10 times weaker than that for human H4R. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo H4R antagonist 1 (Compound 48) shows significant antipruritic and anti-inflammatory efficacy in Oxazolone-induced murine model mimicking human atopic dermatitis (AD) . In the [ 35 S]GTPγS functional assay, H4R antagonist 1 shows inhibitory activity against mouse H4R with an IC 50 of 0.69 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Human H 4 Receptor 27 nM (IC 50 ) Mouse H 4 Receptor 290 nM (IC 50 )

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridopyrazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridopyrazines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Pyridopyrazines
Alternative Parents	Dialkylarylamines Aminopyrazines Pyridines and derivatives Imidolactams Aryl bromides Tetrazoles Heteroaromatic compounds Azetidines Dialkylamines Azacyclic compounds Organobromides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyridopyrazine - Dialkylarylamine - Aminopyrazine - Aryl bromide - Aryl halide - Pyrazine - Pyridine - Imidolactam - Azole - Tetrazole - Heteroaromatic compound - Azetidine - Secondary amine - Secondary aliphatic amine - Azacycle - Amine - Organonitrogen compound - Organobromide - Organohalogen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyridopyrazines. These are aromatic heteropolycyclic compounds containing a pyridine ring fused to a pyrazine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HRH4 Tchem Histamine H4 receptor (2 Activities)

Discover Target: HRH4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH2 Tclin Histamine H2 receptor (5428 Activities)

Discover Target: HRH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH1 Tclin Histamine H1 receptor (7573 Activities)

Discover Target: HRH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)

Discover Target: HTR3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 Activities)

Discover Target: HRH3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hrh4 Histamine H4 receptor (388 Activities)

Discover Target: Hrh4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-(12-bromo-2,3,4,5,8,10-hexazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)-N-methylazetidin-3-amine
INCHI	InChI=1S/C11H11BrN8/c1-13-7-4-19(5-7)10-11-16-17-18-20(11)8-2-6(12)3-14-9(8)15-10/h2-3,7,13H,4-5H2,1H3
InChIKey	ICGICUHMULRYIQ-UHFFFAOYSA-N
Smiles	CNC1CN(C1)C2=NC3=C(C=C(C=N3)Br)N4C2=NN=N4
Isomeric SMILES	CNC1CN(C1)C2=NC3=C(C=C(C=N3)Br)N4C2=NN=N4
PubChem CID	71548412
Molecular Weight	335.16

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 20 mg/mL (59.67 mM; ultrasonic and warming and heat to 60°C)
Molecular Weight	335.160 g/mol
XLogP3	0.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	334.029 Da
Monoisotopic Mass	334.029 Da
Topological Polar Surface Area	84.100 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	364.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration