Protein kinase inhibitor H-89 dihydrochloride | H89 dihydrochloride | H 89 dihydrochloride | N-[2-[[3-(4-Bromophenyl)-2-Propen-1-Yl]Amino]Ethyl]-5-Isoquinolinesulfonamide Hydrochloride (1:2) | H-89 Dihydrochloride Hydrate,N-[2-(P-Bromocinnamylamino)Ethyl]
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Kinase inhibitor, commonly used as a protein kinase A inhibitor (IC 50 = 135 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII (IC 50 values are 120, 80 and 270 nM, respectively).
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.
Application：
H-89 dihydrochloride hydrate inhibits protein kinase A, used in Leydig cells, primary cranial osteoblasts (POBs), rat granular cell line (LH-15 cells) [3], and human umbilical vein endothelial cells (HUVEC).
This compound belongs to the class of organic compounds known as isoquinolines and derivatives. These are aromatic polycyclic compounds containing an isoquinoline moiety, which consists of a benzene ring fused to a pyridine ring and forming benzo[c]pyridine.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1 Citations
J2408428