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GX 201 - ≥98%(HPLC), high purity , CAS No.1788071-27-1

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
G288281
Grouped product items
SKU Size
Availability
 Price Qty
G288281-1mg
1mg
3
$56.90
G288281-5mg
5mg
3
$199.90
G288281-10mg
10mg
2
$312.90
G288281-25mg
25mg
2
$623.90
G288281-50mg
50mg
1
$999.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent and selective Nav1.7 blocker; analgesic

View related series
Ion channel (2197) Membrane Transporter/Ion Channel (1822) Sodium Channel (211)

Basic Description

Synonyms 4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Potent and selective Nav1.7 blocker (IC50= 3.2 nM). Exhibits 10x selectivity for Nav1.7 over Nav1.1, Nav1.2, and Nav1.6 channels. Displays prolonged residency time on the Nav1.7 channel. Chronic dosing increases compound potency ~10-fold and provides effi
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Piperidines
Subclass Benzylpiperidines
Intermediate Tree Nodes Not available
Direct Parent N-benzylpiperidines
Alternative Parents Trifluoromethylbenzenes  2-halobenzoic acids and derivatives  Phenylmethylamines  Phenoxy compounds  Phenol ethers  Benzylamines  Benzoyl derivatives  Fluorobenzenes  Chlorobenzenes  Aralkylamines  Alkyl aryl ethers  Aryl fluorides  Aryl chlorides  Vinylogous halides  Organosulfonic acids and derivatives  Aminosulfonyl compounds  Trialkylamines  Amino acids and derivatives  Azacyclic compounds  Organopnictogen compounds  Organofluorides  Organochlorides  Organic oxides  Hydrocarbon derivatives  Alkyl fluorides  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents N-benzylpiperidine - Trifluoromethylbenzene - Halobenzoic acid or derivatives - 2-halobenzoic acid or derivatives - Benzoic acid or derivatives - Phenoxy compound - Phenylmethylamine - Phenol ether - Benzylamine - Benzoyl - Aralkylamine - Halobenzene - Fluorobenzene - Chlorobenzene - Alkyl aryl ether - Benzenoid - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Aryl chloride - Vinylogous halide - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Tertiary aliphatic amine - Tertiary amine - Amino acid or derivatives - Azacycle - Ether - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as n-benzylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
External Descriptors Not available

Associated Targets(Human)

SCN2A Tclin Sodium channel protein type 2 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN7A Tclin Sodium channel protein type 7 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN5A Tclin Sodium channel protein type 5 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN3A Tclin Sodium channel protein type 3 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN4A Tclin Sodium channel protein type 4 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN1A Tclin Sodium channel protein type 1 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN8A Tclin Sodium channel protein type 8 subunit alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN1A Tclin Sodium channel protein type I alpha subunit (483 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SCN7A Tclin Sodium channel protein type VII alpha subunit (136 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Scn2a Sodium channel protein type II alpha subunit (191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn3a Sodium channel protein type III alpha subunit (24 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn9a Sodium channel protein type IX alpha subunit (69 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn8a Sodium channel protein type VIII alpha subunit (53 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn10a Sodium channel protein type X alpha subunit (425 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn4a Sodium channel protein type IV alpha subunit (55 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-[[1-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]methoxy]-5-cyclopropyl-2-fluoro-N-methylsulfonylbenzamide
INCHI InChI=1S/C25H27ClF4N2O4S/c1-37(34,35)31-24(33)20-11-19(16-2-3-16)23(12-22(20)27)36-14-15-6-8-32(9-7-15)13-17-10-18(25(28,29)30)4-5-21(17)26/h4-5,10-12,15-16H,2-3,6-9,13-14H2,1H3,(H,31,33)
InChIKey KYBPOTYVFWNSGS-UHFFFAOYSA-N
Smiles CS(=O)(=O)NC(=O)C1=C(C=C(C(=C1)C2CC2)OCC3CCN(CC3)CC4=C(C=CC(=C4)C(F)(F)F)Cl)F
Isomeric SMILES CS(=O)(=O)NC(=O)C1=C(C=C(C(=C1)C2CC2)OCC3CCN(CC3)CC4=C(C=CC(=C4)C(F)(F)F)Cl)F
Molecular Weight 563
Reaxy-Rn 28334460
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28334460&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
C2419148 Certificate of Analysis Jan 29, 2024 G288281
C2419149 Certificate of Analysis Jan 29, 2024 G288281
C2419150 Certificate of Analysis Jan 29, 2024 G288281
C2419151 Certificate of Analysis Jan 29, 2024 G288281
C2419152 Certificate of Analysis Jan 29, 2024 G288281
C2419153 Certificate of Analysis Jan 29, 2024 G288281
C2419155 Certificate of Analysis Jan 29, 2024 G288281
C2419156 Certificate of Analysis Jan 29, 2024 G288281
C2419157 Certificate of Analysis Jan 29, 2024 G288281
C2419158 Certificate of Analysis Jan 29, 2024 G288281

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 56.3, Max Conc. mM: 100
Molecular Weight 563.000 g/mol
XLogP3 5.500
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 8
Exact Mass 562.132 Da
Monoisotopic Mass 562.132 Da
Topological Polar Surface Area 84.100 Ų
Heavy Atom Count 37
Formal Charge 0
Complexity 890.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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