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GW768505A free base - 98%, high purity , CAS No.501693-25-0

COA

Grade & Purity:

≥98%

Cas Number: 501693-25-0
Molecular Weight: 573.93
PubChem CID: 5326956

In stock

Item Number

G650427

Grouped product items
SKU	Size	Availability	Price
G650427-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$220.90
G650427-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
G650427-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
G650427-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90

View related series

Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) Tie (12)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 , with a p IC 50 of 7.81 for VEGFR2 . GW768505A free base has anti-angiogenic activity。
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 , with a p IC 50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity. In Vitro GW768505A free base has inhibition for cancer cells growth in NCI-60 panel screening. GW768505A free base is an inhibitor of KDR and TIE2, shows potent inhibition (71–88% inhibition at 100 nM) of the tropomysin-related kinases TRKA, TRKB and TRKC. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:KDR Tie2 Tie-2

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Furans
    - Subclass Diphenylfurans

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Furans
Subclass	Diphenylfurans
Intermediate Tree Nodes	Not available
Direct Parent	2,3-diphenylfurans
Alternative Parents	Trifluoromethylbenzenes N-phenylureas Furo[2,3-d]pyrimidines Phenoxy compounds Anisoles Methoxybenzenes Alkyl aryl ethers Aminopyrimidines and derivatives Fluorobenzenes Primary aromatic amines Aryl fluorides Imidolactams Heteroaromatic compounds Ureas Oxacyclic compounds Azacyclic compounds Alkyl fluorides Organic oxides Organofluorides Organopnictogen compounds Carbonyl compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	2,3-diphenylfuran - Trifluoromethylbenzene - N-phenylurea - Furo[2,3-d]pyrimidine - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Aminopyrimidine - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Primary aromatic amine - Pyrimidine - Benzenoid - Imidolactam - Heteroaromatic compound - Urea - Oxacycle - Azacycle - Ether - Organopnictogen compound - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organofluoride - Carbonyl group - Alkyl halide - Alkyl fluoride - Organic nitrogen compound - Primary amine - Amine - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 2,3-diphenylfurans. These are organic heterocyclic compounds that contain a furan ring substituted with a phenyl group only the C2- and C3-positions.
External Descriptors	organofluorine compound - ureas - furopyrimidine
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TEK Tclin Angiopoietin-1 receptor (3 Activities)

Discover Target: TEK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 (1 Activities)

Discover Target: FLT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 (2 Activities)

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 (6262 Activities)

Discover Target: FLT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TEK Tclin Tyrosine-protein kinase TIE-2 (3348 Activities)

Discover Target: TEK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)

Discover Target: YES1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HFF (3142 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-[4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
INCHI	InChI=1S/C27H19F4N5O3/c1-38-18-9-4-15(5-10-18)23-21(22-24(32)33-13-34-25(22)39-23)14-2-7-17(8-3-14)35-26(37)36-20-12-16(27(29,30)31)6-11-19(20)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37)
InChIKey	FGZIONRFHVNRJB-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3O2)N)C4=CC=C(C=C4)NC(=O)NC5=C(C=CC(=C5)C(F)(F)F)F
Isomeric SMILES	COC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3O2)N)C4=CC=C(C=C4)NC(=O)NC5=C(C=CC(=C5)C(F)(F)F)F
PubChem CID	5326956
Molecular Weight	573.93

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	537.500 g/mol
XLogP3	5.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Exact Mass	537.142 Da
Monoisotopic Mass	537.142 Da
Topological Polar Surface Area	115.000 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	822.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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