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GSTO-IN-2 - ≥98.0%, high purity , CAS No.1202710-57-3

COA

Grade & Purity:

≥98%

Cas Number: 1202710-57-3
Molecular Weight: 620.77
PubChem CID: 75090607

In stock

Item Number

G646501

Grouped product items
SKU	Size	Availability	Price	Qty
G646501-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
G646501-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90

View related series

Amino Acid/Protein Metabolism (1836) Gutathione S-transferase (16) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	GSTO-IN-2 is a glutathione S-transferase inhibitor with IC 50 s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	GSTO-IN-2 is a glutathione S-transferase inhibitor with IC 50 s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1. In Vitro GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)

Names and Identifiers

IUPAC Name	2-amino-5-[[3-carboxy-1-[[17-(4-carboxybutan-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
INCHI	InChI=1S/C33H52N2O9/c1-18(4-11-28(37)38)22-7-8-23-21-6-5-19-16-20(12-14-32(19,2)24(21)13-15-33(22,23)3)44-31(43)26(17-29(39)40)35-27(36)10-9-25(34)30(41)42/h18-26H,4-17,34H2,1-3H3,(H,35,36)(H,37,38)(H,39,40)(H,41,42)
InChIKey	GEYBDXYFLCDBPT-UHFFFAOYSA-N
Smiles	CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)OC(=O)C(CC(=O)O)NC(=O)CCC(C(=O)O)N)C)C
Isomeric SMILES	CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)OC(=O)C(CC(=O)O)NC(=O)CCC(C(=O)O)N)C)C
PubChem CID	75090607
Molecular Weight	620.77

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