Skip to the beginning of the images gallery

GSK2643943A - 98%, high purity , CAS No.2449301-27-1

COA

Grade & Purity:

≥98%

Cas Number: 2449301-27-1
Molecular Weight: 277.3
PubChem CID: 137319705
PubChem SID: 504773490

In stock

Item Number

G413665

Grouped product items
SKU	Size	Availability	Price
G413665-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$107.90
G413665-10mg	10mg	2	$179.90
G413665-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
G413665-50mg	50mg	1	$597.90
G413665-100mg	100mg	1	$1,033.90

USP/UBP Selective Inhibitors

View related series

Cell Cycle/DNA Damage (2602) Deubiquitinase (86) Unfolded Protein Response (214)

Basic Description

Synonyms	1H-Indole-3-carbonitrile,2-amino-6-[2-(3-fluorophenyl)ethenyl]-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information GSK2643943A is an inhibitor ofdeubiquitylating enzyme (DUB)with IC50 of 160 nM forUSP20/Ub-Rho. Targets USP20/Ub-Rho (Cell-free assay) 160 nM

Product Properties

ALogP	3.571
HBD Count	2
Rotatable Bond	2

Names and Identifiers

Pubchem Sid	504773490
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773490
IUPAC Name	2-amino-6-[(E)-2-(3-fluorophenyl)ethenyl]-1H-indole-3-carbonitrile
INCHI	InChI=1S/C17H12FN3/c18-13-3-1-2-11(8-13)4-5-12-6-7-14-15(10-19)17(20)21-16(14)9-12/h1-9,21H,20H2/b5-4+
InChIKey	CGXBPMZRTMXEIA-SNAWJCMRSA-N
Smiles	C1=CC(=CC(=C1)F)C=CC2=CC3=C(C=C2)C(=C(N3)N)C#N
Molecular Weight	277.3
Reaxy-Rn	38910864
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38910864&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
H2202192	Certificate of Analysis	May 12, 2025	G413665
H2202196	Certificate of Analysis	May 12, 2025	G413665
H2202182	Certificate of Analysis	May 12, 2025	G413665

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 55 mg/mL (198.34 mM); Ethanol: 8 mg/mL (28.84 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	55
DMSO(mM) Max Solubility	198.341146772449
Water(mg / mL) Max Solubility	＜1
Molecular Weight	277.290 g/mol
XLogP3	4.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	277.102 Da
Monoisotopic Mass	277.102 Da
Topological Polar Surface Area	65.600 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	441.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration