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Histone Demethylase
GSK LSD1 Dihydrochloride - 98%, high purity , CAS No.1431368-48-7, Inhibitor of lysine demethylase 1A

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GSK LSD1 Dihydrochloride - 98%, high purity , CAS No.1431368-48-7, Inhibitor of lysine demethylase 1A

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 1431368-48-7
Molecular Weight: 289.24
PubChem CID: 71522234
PubChem SID: 504772150

In stock

Item Number

G338771

Grouped product items
SKU	Size	Availability	Price
G338771-5mg	5mg	3	$85.90
G338771-25mg	25mg	3	$384.90
G338771-100mg	100mg	1	$1,385.90

an anti cancer compound that is irreversible mechanism-based inhibitor of LSD1

View related series

Histone Modification (1379) lysine demethylase 1A Inhibitor (8)

Basic Description

Synonyms	N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of lysine demethylase 1A
Product Description	A compound that inhibits cell proliferation in cancer cell lines. It does this by being an irreversible mechanism-based inhibitor of LSD1. LSD1 is part of the family-dependant amine oxidases that include PAOs and MAOs.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Class Organonitrogen compounds
    - Subclass Amines

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Class	Organonitrogen compounds
Subclass	Amines
Intermediate Tree Nodes	Not available
Direct Parent	Aralkylamines
Alternative Parents	Aminopiperidines Benzene and substituted derivatives Dialkylamines Azacyclic compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Aralkylamine - 4-aminopiperidine - Benzenoid - Piperidine - Monocyclic benzene moiety - Azacycle - Organoheterocyclic compound - Secondary amine - Secondary aliphatic amine - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KDM1A Tchem Lysine-specific histone demethylase 1A (2 Activities)

Discover Target: KDM1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)

Discover Target: KDM1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504772150
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772150
IUPAC Name	N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine
INCHI	InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
InChIKey	BASFYRLYJAZPPL-UONOGXRCSA-N
Smiles	C1CNCCC1NC2CC2C3=CC=CC=C3
Isomeric SMILES	C1CNCCC1N[C@@H]2C[C@H]2C3=CC=CC=C3
WGK Germany	3
Alternate CAS	2102933-95-7
Molecular Weight	289.24
Reaxy-Rn	27208703
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27208703&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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3 results found

Lot Number	Certificate Type	Date	Item
I2227268	Certificate of Analysis	Aug 16, 2022	G338771
I2227269	Certificate of Analysis	Aug 16, 2022	G338771
I2227270	Certificate of Analysis	Aug 16, 2022	G338771

Chemical and Physical Properties

Solubility	Soluble in PBS(pH7.2) (~10 mg/ml), ethanol (~0.1 mg/ml), DMSO (~25 mg/ml), DMF (~1 mg/ml), and water (20 mg/ml).
Molecular Weight	216.320 g/mol
XLogP3	1.900
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	216.163 Da
Monoisotopic Mass	216.163 Da
Topological Polar Surface Area	24.100 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	217.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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